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dc.contributor.authorChen, Debbie K.en_US
dc.contributor.authorErb, M. Kelleyen_US
dc.contributor.authorTong, Yunjieen_US
dc.contributor.authorYu, Yangen_US
dc.contributor.authorSassaroli, Angeloen_US
dc.contributor.authorBergethon, Peter R.en_US
dc.contributor.authorFantini, Sergioen_US
dc.date.accessioned2012-01-11T23:13:27Z
dc.date.available2012-01-11T23:13:27Z
dc.date.copyright2010en_US
dc.date.issued2010-9-16en_US
dc.identifier.citationChen, Debbie K., M. Kelley Erb, Yunjie Tong, Yang Yu, Angelo Sassaroli, Peter R. Bergethon, Sergio Fantini. "Spectral and spatial dependence of diffuse optical signals in response to peripheral nerve stimulation" Biomedical Optics Express 1(3): 923-942. (2010)en_US
dc.identifier.issn2156-7085en_US
dc.identifier.urihttp://hdl.handle.net/2144/3320
dc.description.abstractUsing non-invasive, near-infrared spectroscopy we have previously reported optical signals measured at or around peripheral nerves in response to their stimulation. Such optical signals featured amplitudes on the order of 0.1% and peaked about 100 ms after peripheral nerve stimulation in human subjects. Here, we report a study of the spatial and spectral dependence of the optical signals induced by stimulation of the human median and sural nerves, and observe that these optical signals are: (1) unlikely due to either dilation or constriction of blood vessels, (2) not associated with capillary bed hemoglobin, (3) likely due to blood vessel(s) displacement, and (4) unlikely due to fiber-skin optical coupling effects. We conclude that the most probable origin of the optical response to peripheral nerve stimulation is from displacement of blood vessels within the optically probed volume, as a result of muscle twitch in adjacent areas.en_US
dc.description.sponsorshipNational Institutes of Health (R01-NS059933); U.S. Army Medical Acquisition Activity (W81XWH-07-2-0011)en_US
dc.language.isoenen_US
dc.publisherOptical Society of Americaen_US
dc.rightsCopyright 2010 Optical Society of America This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.subject(170.0170) Medical optics and biotechnologyen_US
dc.subject(170.2655) Functional monitoring and imagingen_US
dc.subject(170.3660) Light propagation in tissuesen_US
dc.titleSpectral and Spatial Dependence of Diffuse Optical Signals in Response to Peripheral Nerve Stimulationen_US
dc.typearticleen_US
dc.identifier.doi10.1364/BOE.1.000923en_US
dc.identifier.pmcid3018062en_US


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Copyright 2010 Optical Society of America This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
Except where otherwise noted, this item's license is described as Copyright 2010 Optical Society of America This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.