Show simple item record

dc.contributor.authorHung, Jui-Hungen_US
dc.contributor.authorWhitfield, Troy Wen_US
dc.contributor.authorYang, Tun-Hsiangen_US
dc.contributor.authorHu, Zhenjunen_US
dc.contributor.authorWeng, Zhipingen_US
dc.contributor.authorDeLisi, Charlesen_US
dc.date.accessioned2012-01-09T14:44:44Z
dc.date.available2012-01-09T14:44:44Z
dc.date.copyright2010en_US
dc.date.issued2010-02-26en_US
dc.identifier.citationHung, Jui-Hung, Troy W Whitfield, Tun-Hsiang Yang, Zhenjun Hu, Zhiping Weng, Charles DeLisi. "Identification of Functional Modules That Correlate with Phenotypic Difference: The Influence of Network Topology" Genome Biology 11(2):R23. (2010)en_US
dc.identifier.issn1465-6914en_US
dc.identifier.urihttp://hdl.handle.net/2144/2787
dc.description.abstractA gene set enrichment analysis method for including network topology in the identification of genes involved in phenotypic alterations is described. One of the important challenges to post-genomic biology is relating observed phenotypic alterations to the underlying collective alterations in genes. Current inferential methods, however, invariably omit large bodies of information on the relationships between genes. We present a method that takes account of such information - expressed in terms of the topology of a correlation network - and we apply the method in the context of current procedures for gene set enrichment analysis.en_US
dc.description.sponsorshipNational Institutes of Health (HG004561, GM080625,RR022971, DA19362)en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2010 Hung et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleIdentification of Functional Modules That Correlate with Phenotypic Difference: The Influence of Network Topologyen_US
dc.typearticleen_US
dc.identifier.doi10.1186/gb-2010-11-2-r23en_US
dc.identifier.pubmedid20187943en_US
dc.identifier.pmcid2872883en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Copyright 2010 Hung et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2010 Hung et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.