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dc.contributor.authorFortier, Catherine Brawnen_US
dc.contributor.authorMaksimovskiy, Arkadiy L.en_US
dc.contributor.authorVenne, Jonathan R.en_US
dc.contributor.authorLaFleche, Ginetteen_US
dc.contributor.authorMcGlinchey, Regina E.en_US
dc.date.accessioned2012-01-12T17:50:13Z
dc.date.available2012-01-12T17:50:13Z
dc.date.copyright2009en_US
dc.date.issued2009-7-20en_US
dc.identifier.citationFortier, Catherine Brawn, Arkadiy L. Maksimovskiy, Jonathan R. Venne, Ginette LaFleche, Regina E. McGlinchey. "Silent Trace Eliminates Differential Eyeblink Learning in Abstinent Alcoholics" International Journal of Environmental Research and Public Health 6(7): 2007-2027. (2009)en_US
dc.identifier.issn1660-4601en_US
dc.identifier.urihttp://hdl.handle.net/2144/3453
dc.description.abstractChronic alcoholism has profound effects on the brain, including volume reductions in regions critical for eyeblink classical conditioning (EBCC). The current study challenged abstinent alcoholics using delay (n = 20) and trace (n = 17) discrimination/reversal EBCC. Comparisons revealed a significant difference between delay and trace conditioning performance during reversal (t (35) = 2.08, p < 0.05). The difference between the two tasks for discrimination was not significant (p = 0.44). These data support the notion that alcoholics are increasingly impaired in the complex task of reversing a previously learned discrimination when a silent trace interval is introduced. Alcoholics' impairment in flexibly altering learned associations may be central to their continued addiction.en_US
dc.description.sponsorshipNational Istitute of Health (NIAAA 14205)en_US
dc.language.isoenen_US
dc.publisherMolecular Diversity Preservation International (MDPI)en_US
dc.rightsCopyright 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0en_US
dc.subjectAlcoholen_US
dc.subjectEyeblink classical conditioningen_US
dc.subjectLearningen_US
dc.subjectDiscriminationen_US
dc.subjectReversalen_US
dc.titleSilent Trace Eliminates Differential Eyeblink Learning in Abstinent Alcoholicsen_US
dc.typearticleen_US
dc.identifier.doi10.3390/ijerph6072007en_US
dc.identifier.pubmedid19742168en_US
dc.identifier.pmcid2738895en_US


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Copyright 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
Except where otherwise noted, this item's license is described as Copyright 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.