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dc.contributor.authorFavaretto, Paolaen_US
dc.contributor.authorBhutkar, Arjunen_US
dc.contributor.authorSmith, Temple F.en_US
dc.date.accessioned2012-01-12T17:46:42Z
dc.date.available2012-01-12T17:46:42Z
dc.date.issued2005-09-09en_US
dc.identifier.citationFavaretto, Paola, Arjun Bhutkar, Temple F. Smith. "Constraining ribosomal RNA conformational space" Nucleic Acids Research 33(16): 5106-5111. (2005)en_US
dc.identifier.issn1362-4962en_US
dc.identifier.urihttp://hdl.handle.net/2144/3441
dc.description.abstractDespite the potential for many possible secondary-structure conformations, the native sequence of ribosomal RNA (rRNA) is able to find the correct and universally conserved core fold. This study reports a computational analysis investigating two mechanisms that appear to constrain rRNA secondary-structure conformational space: ribosomal proteins and rRNA sequence composition. The analysis was carried out by using rRNA–ribosomal protein interaction data for the Escherichia coli 16S rRNA and free energy minimization software for secondary-structure prediction. The results indicate that selection pressures on rRNA sequence composition and ribosomal protein–rRNA interaction play a key role in constraining the rRNA secondary structure to a single stable form.en_US
dc.description.sponsorshipNational Science Foundation (DBI-0205512); Boston Universityen_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.titleConstraining Ribosomal RNA Conformational Spaceen_US
dc.typearticleen_US
dc.identifier.doi10.1093/nar/gki805en_US
dc.identifier.pubmedid16155182en_US
dc.identifier.pmcid1214544en_US


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