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dc.contributor.authorSmith, Temple Fen_US
dc.contributor.authorLee, Jung Cen_US
dc.contributor.authorGutell, Robin Ren_US
dc.contributor.authorHartman, Hymanen_US
dc.date.accessioned2012-01-12T17:46:41Z
dc.date.available2012-01-12T17:46:41Z
dc.date.copyright2008en_US
dc.date.issued2008-4-22en_US
dc.identifier.citationSmith, Temple F, Jung C Lee, Robin R Gutell, Hyman Hartman. "The origin and evolution of the ribosome" Biology Direct 3:16. (2008)en_US
dc.identifier.issn1745-6150en_US
dc.identifier.urihttp://hdl.handle.net/2144/3439
dc.description.abstractBACKGROUND. The origin and early evolution of the active site of the ribosome can be elucidated through an analysis of the ribosomal proteins' taxonomic block structures and their RNA interactions. Comparison between the two subunits, exploiting the detailed three-dimensional structures of the bacterial and archaeal ribosomes, is especially informative. RESULTS. The analysis of the differences between these two sites can be summarized as follows: 1) There is no self-folding RNA segment that defines the decoding site of the small subunit; 2) there is one self-folding RNA segment encompassing the entire peptidyl transfer center of the large subunit; 3) the protein contacts with the decoding site are made by a set of universal alignable sequence blocks of the ribosomal proteins; 4) the majority of those peptides contacting the peptidyl transfer center are made by bacterial or archaeal-specific sequence blocks. CONCLUSION. These clear distinctions between the two subunit active sites support an earlier origin for the large subunit's peptidyl transferase center (PTC) with the decoding site of the small subunit being a later addition to the ribosome. The main implications are that a single self-folding RNA, in conjunction with a few short stabilizing peptides, formed the precursor of the modern ribosomal large subunit in association with a membrane. REVIEWERS. This article was reviewed by Jerzy Jurka, W. Ford Doolittle, Eugene Shaknovich, and George E. Fox (nominated by Jerzy Jurka).en_US
dc.description.sponsorshipNational Science Foundation (DBI-051600); National Institutes of Health (GM067317); Welch Foundation (F1427)en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2008 Smith et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleThe Origin and Evolution of the Ribosomeen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1745-6150-3-16en_US
dc.identifier.pubmedid18430223en_US
dc.identifier.pmcid2386862en_US


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Copyright 2008 Smith et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2008 Smith et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.