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dc.contributor.authorGrenz, Almuten_US
dc.contributor.authorOsswald, Hartmuten_US
dc.contributor.authorEckle, Tobiasen_US
dc.contributor.authorYang, Danen_US
dc.contributor.authorZhang, Huaen_US
dc.contributor.authorTran, Zung Vuen_US
dc.contributor.authorKlingel, Karinen_US
dc.contributor.authorRavid, Katyaen_US
dc.contributor.authorEltzschig, Holger K.en_US
dc.date.accessioned2012-01-12T17:43:50Z
dc.date.available2012-01-12T17:43:50Z
dc.date.issued2008-6-24
dc.identifier.citationGrenz, Almut, Hartmut Osswald, Tobias Eckle, Dan Yang, Hua Zhang, Zung Vu Tran, Karin Klingel, Katya Ravid, Holger K Eltzschig. "The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia" PLoS Medicine 5(6):e137. (2008)
dc.identifier.issn1549-1676
dc.identifier.urihttp://hdl.handle.net/2144/3431
dc.description.abstractBACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortality in clinical settings, and strategies to improve renal resistance to ischemia are urgently needed. Here, we identified a novel pathway of renal protection from ischemia using ischemic preconditioning (IP). METHODS AND FINDINGS. For this purpose, we utilized a recently developed model of renal ischemia and IP via a hanging weight system that allows repeated and atraumatic occlusion of the renal artery in mice, followed by measurements of specific parameters or renal functions. Studies in gene-targeted mice for each individual adenosine receptor (AR) confirmed renal protection by IP in A1−/−, A2A−/−, or A3AR−/− mice. In contrast, protection from ischemia was abolished in A2BAR−/− mice. This protection was associated with corresponding changes in tissue inflammation and nitric oxide production. In accordance, the A2BAR-antagonist PSB1115 blocked renal protection by IP, while treatment with the selective A2BAR-agonist BAY 60–6583 dramatically improved renal function and histology following ischemia alone. Using an A2BAR-reporter model, we found exclusive expression of A2BARs within the reno-vasculature. Studies using A2BAR bone-marrow chimera conferred kidney protection selectively to renal A2BARs. CONCLUSIONS. These results identify the A2BAR as a novel therapeutic target for providing potent protection from renal ischemia. Using gene-targeted mice, Holger Eltzschig and colleagues identify the A2B adenosine receptor as a novel therapeutic target for providing protection from renal ischemia.en_US
dc.description.sponsorshipDeutsche Forschungsgemeinschaft Research Fellowship (GR2121/1–1); Fortune grant (1416-0-0); Interdisciplinary Centre for Clinical Research Verbundprojekt (1597-0-0); University of Tu¨ bingen; German Research Foundation (EL274/2–2); Foundation for Anesthesia Education and Research; IZKF Nachwuchsgruppe (1605-0-0)en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.titleThe Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemiaen_US
dc.typearticleen_US
dc.identifier.doi10.1371/journal.pmed.0050137
dc.identifier.pubmedid18578565
dc.identifier.pmcid2504049


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