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dc.contributor.authorBare, Lance A.en_US
dc.contributor.authorRuiz-Narvaéz, Edward A.en_US
dc.contributor.authorTong, Carmen H.en_US
dc.contributor.authorArellano, Andre R.en_US
dc.contributor.authorRowland, Charles M.en_US
dc.contributor.authorCatanese, Joseph J.en_US
dc.contributor.authorSacks, Frank M.en_US
dc.contributor.authorDevlin, James J.en_US
dc.contributor.authorCampos, Hanniaen_US
dc.date.accessioned2012-01-12T17:43:32Z
dc.date.available2012-01-12T17:43:32Z
dc.date.issued2010-9-29en_US
dc.identifier.citationBare, Lance A., Edward A. Ruiz-Narvaéz, Carmen H. Tong, Andre R. Arellano, Charles M. Rowland, Joseph J. Catanese, Frank M. Sacks, James J. Devlin, Hannia Campos. "Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Population" PLoS ONE 5(9): e13081. (2010)en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/2144/3429
dc.description.abstractBACKGROUND AND METHODOLOGY. The 719Arg allele of KIF6 (rs20455) was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with non-fatal myocardial infarction (MI) in a case-control study of an admixed population from the Central Valley of Costa Rica. Genotypes of the KIF6 variant were determined for 4,134 men and women. Cases (1,987) had survived a first MI; controls (2,147) had no history of MI and were matched to cases by age, sex, and area of residence. We tested the association between the KIF6 719Arg allele and non-fatal MI by conditional logistic regression and adjusted for admixture of founder populations. PRINCIPAL FINDINGS. Compared with the reference Trp/Trp homozygotes, KIF6 719Arg carriers were not at significantly higher risk for non-fatal MI in this study after adjustment for traditional risk factors or admixture (OR=1.12; 95%CI, 0.98-1.28). Heterozygotes of the KIF6 Trp719Arg variant were at increased risk of non-fatal MI: the adjusted odds ratio was 1.16 (95% confidence interval, 1.01-1.34), but this association would not be significant after a multiple testing correction. CONCLUSIONS/SIGNIFICANCE. We found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica.en_US
dc.description.sponsorshipNational Institutes of Health (HL49086, HL60692); American Heart Association (0625819T)en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsBare et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.titleInvestigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Populationen_US
dc.typearticleen_US
dc.identifier.doi10.1371/journal.pone.0013081en_US
dc.identifier.pubmedid20927332en_US
dc.identifier.pmcid2947524en_US


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