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dc.contributor.authorCardinal, Matthewen_US
dc.contributor.authorPhillips, Taniaen_US
dc.contributor.authorEisenbud, David Een_US
dc.contributor.authorHarding, Keithen_US
dc.contributor.authorMansbridge, Jonathanen_US
dc.contributor.authorArmstrong, David Gen_US
dc.date.accessioned2012-01-12T17:35:45Z
dc.date.available2012-01-12T17:35:45Z
dc.date.copyright2009en_US
dc.date.issued2009-3-31en_US
dc.identifier.citationCardinal, Matthew, Tania Phillips, David E Eisenbud, Keith Harding, Jonathan Mansbridge, David G Armstrong. "Nonlinear modeling of venous leg ulcer healing rates" BMC Dermatology 9:2. (2009)en_US
dc.identifier.issn1471-5945en_US
dc.identifier.urihttp://hdl.handle.net/2144/3402
dc.description.abstractBACKGROUND. The purpose of this manuscript was to determine whether the change in wound surface area over time could be described through nonlinear mathematics. METHODS. We studied 3,588 serial wound tracings of 338 venous leg ulcers (VLUs) that had been followed during a controlled, prospective, randomized trial of two topical wound treatments. RESULTS. A majority (72%) of VLUs exhibited surface area reduction via an exponential decay model, particularly during the early stages of healing. These results were consistent with the mechanics of wound contraction and epithelial cell proliferation, supported by the higher frequency at which exponential surface area reduction associated with full wound closure (35% of wounds that fit the exponential model healed vs. 21% of wounds that did not fit the exponential model completely healed during the study period, p = 0.018). Goodness-of-fit statistics suggested that much of the individual variation in healing could be described as nonlinear variation from the exponential model. CONCLUSION. We believe that parameter estimates from a mathematical model may provide a more accurate quantification of wound healing rates, and that similar models may someday reach routine use in comparing the efficacy of various treatments in routine practice and in product registration trials.en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2009 Cardinal et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleNonlinear Modeling of Venous Leg Ulcer Healing Ratesen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1471-5945-9-2en_US
dc.identifier.pubmedid19335882en_US
dc.identifier.pmcid2672927en_US


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Copyright 2009 Cardinal et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2009 Cardinal et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.