Growth Factors in Lung Development and Disease: Friends or Foe?


Show simple item record Desai, Tushar J en_US Cardoso, Wellington V en_US 2012-01-12T17:19:49Z 2012-01-12T17:19:49Z 2001 en_US 2001-10-9 en_US
dc.identifier.citation Desai, Tushar J, Wellington V Cardoso. "Growth factors in lung development and disease: friends or foe?" Respiratory Research 3(1):2. (2001) en_US
dc.identifier.issn 1465-993X en_US
dc.description.abstract Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor β1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents. en_US
dc.description.sponsorship National Heart, Lung, and Blood Institute (PO1HL47049) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2001 BioMed Central Ltd en_US
dc.subject Airway branching en_US
dc.subject Growth factors en_US
dc.subject Lung development en_US
dc.subject Lung injury-repair en_US
dc.title Growth Factors in Lung Development and Disease: Friends or Foe? en_US
dc.type article en_US
dc.identifier.doi 10.1186/rr169 en_US
dc.identifier.pubmedid 11806837 en_US
dc.identifier.pmcid 64813 en_US

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