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dc.contributor.authorDesai, Tushar J.en_US
dc.contributor.authorCardoso, Wellington V.en_US
dc.date.accessioned2012-01-12T17:19:49Z
dc.date.available2012-01-12T17:19:49Z
dc.date.copyright2001
dc.date.issued2001-10-9
dc.identifier.citationDesai, Tushar J, Wellington V Cardoso. "Growth factors in lung development and disease: friends or foe?" Respiratory Research 3(1):2. (2001)
dc.identifier.issn1465-993X
dc.identifier.urihttp://hdl.handle.net/2144/3395
dc.description.abstractGrowth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor β1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents.en_US
dc.description.sponsorshipNational Heart, Lung, and Blood Institute (PO1HL47049)en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2001 BioMed Central Ltden_US
dc.subjectAirway branchingen_US
dc.subjectGrowth factorsen_US
dc.subjectLung developmenten_US
dc.subjectLung injury-repairen_US
dc.titleGrowth Factors in Lung Development and Disease: Friends or Foe?en_US
dc.typearticleen_US
dc.identifier.doi10.1186/rr169
dc.identifier.pubmedid11806837
dc.identifier.pmcid64813


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