Role of Free Radicals in the Pathogenesis of Acute Chest Syndrome in Sickle Cell Disease


Show simple item record Klings, Elizabeth S en_US Farber, Harrison W en_US 2012-01-12T17:19:49Z 2012-01-12T17:19:49Z 2001 en_US 2001-7-13 en_US
dc.identifier.citation Klings, Elizabeth S, Harrison W Farber. "Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease" Respiratory Research 2(5): 280-285. (2001) en_US
dc.identifier.issn 1465-993X en_US
dc.description.abstract Acute chest syndrome (ACS) of sickle cell disease (SCD) is characterized pathologically by vaso-occlusive processes that result from abnormal interactions between sickle red blood cells (RBCs), white blood cells (WBCs) and/or platelets, and the vascular endothelium. One potential mechanism of vascular damage in ACS is by generation of oxygen-related molecules, such as superoxide (O2-), hydrogen peroxide (H2O2), peroxynitrite (ONOO-), and the hydroxyl (•OH) radical. The present review summarizes the evidence for alterations in oxidant stress during ACS of SCD, and the potential contributions of RBCs, WBCs and the vascular endothelium to this process. en_US
dc.description.sponsorship American Lung Association (RT-030-N); American Heart Association (0150155N) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2001 BioMed Central Ltd en_US
dc.subject Acute chest syndrome (ACS) en_US
dc.subject Endothelium en_US
dc.subject Hemoglobin en_US
dc.subject Nitric oxide (NO) en_US
dc.subject Oxidant stress en_US
dc.title Role of Free Radicals in the Pathogenesis of Acute Chest Syndrome in Sickle Cell Disease en_US
dc.type article en_US
dc.identifier.doi 10.1186/rr70 en_US
dc.identifier.pubmedid 11686897 en_US
dc.identifier.pmcid 59517 en_US

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