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dc.contributor.authorRosenthal, Rosalind A.en_US
dc.contributor.authorHuffman, Karl D.en_US
dc.contributor.authorFisette, Leslie W.en_US
dc.contributor.authorDamphousse, Christy A.en_US
dc.contributor.authorCallaway, Wyeth B.en_US
dc.contributor.authorMalfroy, Bernarden_US
dc.contributor.authorDoctrow, Susan R.en_US
dc.date.accessioned2012-01-12T17:19:48Z
dc.date.available2012-01-12T17:19:48Z
dc.date.issued2009-6-6en_US
dc.identifier.citationRosenthal, Rosalind A., Karl D. Huffman, Leslie W. Fisette, Christy A. Damphousse, Wyeth B. Callaway, Bernard Malfroy, Susan R. Doctrow. "Orally available Mn porphyrins with superoxide dismutase and catalase activities" Journal of Biological Inorganic Chemistry 14(6): 979-991. (2009)en_US
dc.identifier.issn1432-1327en_US
dc.identifier.urihttp://hdl.handle.net/2144/3391
dc.description.abstractSuperoxide dismutase/catalase mimetics, such as salen Mn complexes and certain metalloporphyrins, catalytically neutralize reactive oxygen and nitrogen species, which have been implicated in the pathogenesis of many serious diseases. Both classes of mimetic are protective in animal models of oxidative stress. However, only AEOL11207 and EUK-418, two uncharged Mn porphyrins, have been shown to be orally bioavailable. In this study, EUK-418 and several new analogs (the EUK-400 series) were synthesized and shown to exhibit superoxide dismutase, catalase, and peroxidase activities in vitro. Some also protected PC12 cells against staurosporine-induced cell death. All EUK-400 compounds were stable in simulated gastric fluid, and most were substantially more lipophilic than the salen Mn complexes EUK-189 and EUK-207, which lack oral activity. Pharmacokinetics studies demonstrate the presence of all EUK-400 series compounds in the plasma of rats after oral administration. These EUK-400 series compounds are potential oral therapeutic agents for cellular damage caused by oxidative stress. ELECTRONIC SUPPLEMENTARY MATERIAL. The online version of this article (doi:10.1007/s00775-009-0550-4) contains supplementary material, which is available to authorized users.en_US
dc.description.sponsorshipNational Institute of Allergy and Infection Disease (U19-A1067734)en_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.rightsCopyright The Author(s) 2009en_US
dc.subjectManganese porphyrinsen_US
dc.subjectEUK-400 series compoundsen_US
dc.subjectOxidative stressen_US
dc.subjectApoptosisen_US
dc.subjectSuperoxide dismutase/catalase mimeticsen_US
dc.titleOrally Available Mn Porphyrins with Superoxide Dismutase and Catalase Activitiesen_US
dc.typearticleen_US
dc.identifier.doi10.1007/s00775-009-0550-4en_US
dc.identifier.pubmedid19504132en_US
dc.identifier.pmcid2716445en_US


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