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dc.contributor.authorYi, Ken_US
dc.contributor.authorMujat, Men_US
dc.contributor.authorPark, B Hen_US
dc.contributor.authorSun, Wen_US
dc.contributor.authorMiller, J Wen_US
dc.contributor.authorSeddon, J Men_US
dc.contributor.authorYoung, L Hen_US
dc.contributor.authorde Boer, J Fen_US
dc.contributor.authorChen, T Cen_US
dc.date.accessioned2012-01-12T16:41:19Z
dc.date.available2012-01-12T16:41:19Z
dc.date.copyright2009en_US
dc.date.issued2008-12-3en_US
dc.identifier.citationYi, K, M Mujat, B H Park, W Sun, J W Miller, J M Seddon, L H Young, J F de Boer, T C Chen. "Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration" The British Journal of Ophthalmology 93(2): 176-181. (2008)en_US
dc.identifier.issn1468-2079en_US
dc.identifier.urihttp://hdl.handle.net/2144/3356
dc.description.abstractBACKGROUND/AIMS:. To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomical changes in eyes with non-neovascular age-related macular degeneration (AMD) compared with time domain optical coherence tomography (TDOCT). METHODS:. Images were obtained from three eyes of three patients with AMD using an experimental SDOCT system. Both a titanium–sapphire (Ti:sapphire) laser and a superluminescent diode (SLD) were used as a broadband light source to achieve cross-sectional images of the retina. A qualitative and quantitative analysis was performed for structural changes associated with non-neovascular AMD. An automated algorithm was developed to analyse drusen area and volume from SDOCT images. TDOCT was performed using the fast macular scan (StratusOCT, Carl Zeiss Meditec, Dublin, California). RESULTS:. SDOCT images can demonstrate structural changes associated with non-neovascular AMD. A new SDOCT algorithm can determine drusen area, drusen volume and proportion of drusen. CONCLUSIONS:. With new algorithms to determine drusen area and volume and its unprecedented simultaneous ultra-high speed ultra-high resolution imaging, SDOCT can improve the evaluation of structural abnormalities in non-neovascular AMD.en_US
dc.description.sponsorshipNational Institutes of Health (RO1EY014975, RO1-RR19768); Nideken_US
dc.language.isoenen_US
dc.publisherBMJ Publishing Groupen_US
dc.rightsCopyright Yi et al 2009 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en_US
dc.titleSpectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age-Related Macular Degenerationen_US
dc.typearticleen_US
dc.identifier.doi10.1136/bjo.2008.137356en_US
dc.identifier.pubmedid18697811en_US
dc.identifier.pmcid2628537en_US


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Copyright Yi et al 2009 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright Yi et al 2009 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.