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dc.contributor.authorKim, Philip Men_US
dc.contributor.authorSboner, Andreaen_US
dc.contributor.authorXia, Yuen_US
dc.contributor.authorGerstein, Marken_US
dc.date.accessioned2012-01-12T16:40:40Z
dc.date.available2012-01-12T16:40:40Z
dc.date.issued2008-03-25en_US
dc.identifier.citationKim, Philip M, Andrea Sboner, Yu Xia, Mark Gerstein. "The role of disorder in interaction networks: a structural analysis" Molecular Systems Biology 4:179. (2008)en_US
dc.identifier.issn1744-4292en_US
dc.identifier.urihttp://hdl.handle.net/2144/3352
dc.description.abstractRecent studies have emphasized the value of including structural information into the topological analysis of protein networks. Here, we utilized structural information to investigate the role of intrinsic disorder in these networks. Hub proteins tend to be more disordered than other proteins (i.e. the proteome average); however, we find this only true for those with one or two binding interfaces ('single'-interface hubs). In contrast, the distribution of disordered residues in multi-interface hubs is indistinguishable from the overall proteome. Surprisingly, we find that the binding interfaces in single-interface hubs are highly structured, as is the case for multi-interface hubs. However, the binding partners of single-interface hubs tend to have a higher level of disorder than the proteome average, suggesting that their binding promiscuity is related to the disorder of their binding partners. In turn, the higher level of disorder of single-interface hubs can be partly explained by their tendency to bind to each other in a cascade. A good illustration of this trend can be found in signaling pathways and, more specifically, in kinase cascades. Finally, our findings have implications for the current controversy related to party and date-hubs.en_US
dc.description.sponsorshipNational Institutes of Health (RR19895)en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.subjectHubsen_US
dc.subjectIntrinsic disorderen_US
dc.subjectStructural networksen_US
dc.titleThe Role of Disorder in Interaction Networks: A Structural Analysisen_US
dc.typearticleen_US
dc.identifier.doi10.1038/msb.2008.16en_US
dc.identifier.pubmedid18364713en_US
dc.identifier.pmcid2290937en_US


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This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.
Except where otherwise noted, this item's license is described as This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.