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dc.contributor.authorYu, Lilien_US
dc.contributor.authorTucci, Valteren_US
dc.contributor.authorKishi, Shujien_US
dc.contributor.authorZhdanova, Irina V.en_US
dc.date.accessioned2012-01-11T23:13:28Z
dc.date.available2012-01-11T23:13:28Z
dc.date.issued2006-12-20en_US
dc.identifier.citationYu, Lili, Valter Tucci, Shuji Kishi, Irina V. Zhdanova. "Cognitive Aging in Zebrafish" PLoS ONE 1(1):e14. (2006)en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/2144/3324
dc.description.abstractBACKGROUND. Age-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the intrinsic and environmental factors that determine the deterioration or preservation of cognitive abilities throughout life. METHODOLOGY/PRINCIPAL FINDINGS. Behavior of wild-type, mutant and gamma-irradiated zebrafish (Danio rerio) was documented using image-analysis technique. Conditioned responses to spatial, visual and temporal cues were investigated in young, middle-aged and old animals. The results demonstrate that zebrafish aging is associated with changes in cognitive responses to emotionally positive and negative experiences, reduced generalization of adaptive associations, increased stereotypic and reduced exploratory behavior and altered temporal entrainment. Genetic upregulation of cholinergic transmission attenuates cognitive decline in middle-aged achesb55/+ mutants, compared to wild-type siblings. In contrast, the genotoxic stress of gamma-irradiation accelerates the onset of cognitive impairment in young zebrafish. CONCLUSIONS/SIGNIFICANCE. These findings would allow the use of powerful molecular biological resources accumulated in the zebrafish field to address the mechanisms of cognitive senescence, and promote the search for therapeutic strategies which may attenuate age-related cognitive decline.en_US
dc.description.sponsorshipNational Institutes of Health (MH065528, AG02264); Chaikin-Wile foundation; Ellison Medical Foundationen_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.titleCognitive Aging in Zebrafishen_US
dc.typearticleen_US
dc.identifier.doi10.1371/journal.pone.0000014en_US
dc.identifier.pubmedid17183640en_US
dc.identifier.pmcid1762370en_US


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