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dc.contributor.authorYaar, Minaen_US
dc.contributor.authorEller, Mark Sen_US
dc.contributor.authorPanova, Izabelaen_US
dc.contributor.authorKubera, Johnen_US
dc.contributor.authorWee, Lee Hngen_US
dc.contributor.authorCowan, Kenneth Hen_US
dc.contributor.authorGilchrest, Barbara Aen_US
dc.date.accessioned2012-01-11T22:29:18Z
dc.date.available2012-01-11T22:29:18Z
dc.date.copyright2007en_US
dc.date.issued2007-1-26en_US
dc.identifier.citationYaar, Mina, Mark S Eller, Izabela Panova, John Kubera, Lee Hng Wee, Kenneth H Cowan, Barbara A Gilchrest. "Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells" Breast Cancer Research 9(1):R13. (2007)en_US
dc.identifier.issn1465-542Xen_US
dc.identifier.urihttp://hdl.handle.net/2144/3305
dc.description.abstractINTRODUCTION. Cancer is a leading cause of death in Americans. We have identified an inducible cancer avoidance mechanism in cells that reduces mutation rate, reduces and delays carcinogenesis after carcinogen exposure, and induces apoptosis and/or senescence of already transformed cells by simultaneously activating multiple overlapping and redundant DNA damage response pathways. METHODS. The human breast carcinoma cell line MCF-7, the adriamycin-resistant MCF-7 (Adr/MCF-7) cell line, as well as normal human mammary epithelial (NME) cells were treated with DNA oligonucleotides homologous to the telomere 3' overhang (T-oligos). SCID mice received intravenous injections of MCF-7 cells followed by intravenous administration of T-oligos. RESULTS. Acting through ataxia telangiectasia mutated (ATM) and its downstream effectors, T-oligos induced apoptosis and senescence of MCF-7 cells but not NME cells, in which these signaling pathways were induced to a far lesser extent. In MCF-7 cells, experimental telomere loop disruption caused identical responses, consistent with the hypothesis that T-oligos act by mimicking telomere overhang exposure. In vivo, T-oligos greatly prolonged survival of SCID mice following intravenous injection of human breast carcinoma cells. CONCLUSION. By inducing DNA damage-like responses in MCF-7 cells, T-oligos provide insight into innate cancer avoidance mechanisms and may offer a novel approach to treatment of breast cancer and other malignancies.en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2007 Yaar et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleTelomeric DNA Induces Apoptosis and Senescence of Human Breast Carcinoma Cellsen_US
dc.typearticleen_US
dc.identifier.doi10.1186/bcr1646en_US
dc.identifier.pubmedid17257427en_US
dc.identifier.pmcid1851376en_US


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Copyright 2007 Yaar et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2007 Yaar et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.