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dc.contributor.authorWu, Yuntaoen_US
dc.contributor.authorYoder, Alysonen_US
dc.contributor.authorYu, Dongyangen_US
dc.contributor.authorWang, Weifengen_US
dc.contributor.authorLiu, Juanen_US
dc.contributor.authorBarrett, Traceyen_US
dc.contributor.authorWheeler, Daviden_US
dc.contributor.authorSchlauch, Karenen_US
dc.date.accessioned2012-01-11T22:28:24Z
dc.date.available2012-01-11T22:28:24Z
dc.date.copyright2008en_US
dc.date.issued2008-10-17en_US
dc.identifier.citationWu, Yuntao, Alyson Yoder, Dongyang Yu, Weifeng Wang, Juan Liu, Tracey Barrett, David Wheeler, Karen Schlauch. "Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study" Retrovirology 5:95. (2008)en_US
dc.identifier.issn1742-4690en_US
dc.identifier.urihttp://hdl.handle.net/2144/3302
dc.description.abstractCofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. Previously, we demonstrated that during HIV-1 infection of resting CD4 T cells, the viral envelope-CXCR4 signaling activates cofilin to overcome the static cortical actin restriction. In this pilot study, we have extended this in vitro observation and examined cofilin phosphorylation in resting CD4 T cells purified from the peripheral blood of HIV-1-infected patients. Here, we report that the resting T cells from infected patients carry significantly higher levels of active cofilin, suggesting that these resting cells have been primed in vivo in cofilin activity to facilitate HIV-1 infection. HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell migration and activation that could contribute to viral pathogenesis.en_US
dc.description.sponsorshipDepartment of Defense (National Defense Science and Engineering Fellowship); National Institute of Allergy and Infectious Diseases (AI069981)en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2008 Wu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleCofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Studyen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1742-4690-5-95en_US
dc.identifier.pubmedid18928553en_US
dc.identifier.pmcid2576353en_US


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Copyright 2008 Wu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2008 Wu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.