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dc.contributor.authorCastelletti, Eleonoraen_US
dc.contributor.authorLo Caputo, Sergioen_US
dc.contributor.authorKuhn, Louiseen_US
dc.contributor.authorBorelli, Manuelaen_US
dc.contributor.authorGajardo, Johannaen_US
dc.contributor.authorSinkala, Mosesen_US
dc.contributor.authorTrabattoni, Dariaen_US
dc.contributor.authorKankasa, Chipepoen_US
dc.contributor.authorLauri, Eleonoraen_US
dc.contributor.authorClivio, Albertoen_US
dc.contributor.authorPiacentini, Lucaen_US
dc.contributor.authorBray, Dorothy H.en_US
dc.contributor.authorAldrovandi, Grace M.en_US
dc.contributor.authorThea, Donald M.en_US
dc.contributor.authorVeas, Franciscoen_US
dc.contributor.authorNebuloni, Manuelaen_US
dc.contributor.authorMazzotta, Francescoen_US
dc.contributor.authorClerici, Marioen_US
dc.date.accessioned2012-01-11T21:43:54Z
dc.date.available2012-01-11T21:43:54Z
dc.date.issued2007-10-3en_US
dc.identifier.citationCastelletti, Eleonora, Sergio Lo Caputo, Louise Kuhn, Manuela Borelli, Johanna Gajardo, Moses Sinkala, Daria Trabattoni, Chipepo Kankasa, Eleonora Lauri, Alberto Clivio, Luca Piacentini, Dorothy H. Bray, Grace M. Aldrovandi, Donald M. Thea, Francisco Veas, Manuela Nebuloni, Francesco Mazzotta, Mario Clerici. "The Mucosae-Associated Epithelial Chemokine (MEC/CCL28) Modulates Immunity in HIV Infection" PLoS ONE 2(10):e969. (2007)en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/2144/3247
dc.description.abstractBACKGROUND. CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propria (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model. METHODOLOGY/FINDINGS. CCL28 was augmented in breast milk (BM) plasma and saliva of HIV-infected and –exposed individuals; CCR3+ and CCR10+ B lymphocytes were increased in these same individuals. Additionally: 1) CCL28 concentration in BM was associated with longer survival in HIV vertically-infected children; and 2) gastro-intestinal mucosal IgA-ASC were significantly increased in VSV-immunized mice receiving CCL28. CONCLUSIONS. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28-including constructs should be considered in mucosal vaccines to prevent HIV infection of the gastro-intestinal MLP via modulation of IgA-ASC.en_US
dc.description.sponsorshipIstituto Superiore di Sanita' "Programma Nazionale di Ricerca sull' AIDS"; DG Right to Health and Solidarity Policy; EMPRO and AVIP EC WP6 Projects; Japan Health Science Foundation; National Institutes of Child Health and Human Development (HD 39611, HD 40777)en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.titleThe Mucosae-Associated Epithelial Chemokine (MEC/CCL28) Modulates Immunity in HIV Infectionen_US
dc.typearticleen_US
dc.identifier.doi10.1371/journal.pone.0000969en_US
dc.identifier.pubmedid17912348en_US
dc.identifier.pmcid1989139en_US


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