The Mucosae-Associated Epithelial Chemokine (MEC/CCL28) Modulates Immunity in HIV Infection


Show simple item record Castelletti, Eleonora en_US Lo Caputo, Sergio en_US Kuhn, Louise en_US Borelli, Manuela en_US Gajardo, Johanna en_US Sinkala, Moses en_US Trabattoni, Daria en_US Kankasa, Chipepo en_US Lauri, Eleonora en_US Clivio, Alberto en_US Piacentini, Luca en_US Bray, Dorothy H. en_US Aldrovandi, Grace M. en_US Thea, Donald M. en_US Veas, Francisco en_US Nebuloni, Manuela en_US Mazzotta, Francesco en_US Clerici, Mario en_US 2012-01-11T21:43:54Z 2012-01-11T21:43:54Z 2007-10-3 en_US
dc.identifier.citation Castelletti, Eleonora, Sergio Lo Caputo, Louise Kuhn, Manuela Borelli, Johanna Gajardo, Moses Sinkala, Daria Trabattoni, Chipepo Kankasa, Eleonora Lauri, Alberto Clivio, Luca Piacentini, Dorothy H. Bray, Grace M. Aldrovandi, Donald M. Thea, Francisco Veas, Manuela Nebuloni, Francesco Mazzotta, Mario Clerici. "The Mucosae-Associated Epithelial Chemokine (MEC/CCL28) Modulates Immunity in HIV Infection" PLoS ONE 2(10):e969. (2007) en_US
dc.identifier.issn 1932-6203 en_US
dc.description.abstract BACKGROUND. CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propria (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model. METHODOLOGY/FINDINGS. CCL28 was augmented in breast milk (BM) plasma and saliva of HIV-infected and –exposed individuals; CCR3+ and CCR10+ B lymphocytes were increased in these same individuals. Additionally: 1) CCL28 concentration in BM was associated with longer survival in HIV vertically-infected children; and 2) gastro-intestinal mucosal IgA-ASC were significantly increased in VSV-immunized mice receiving CCL28. CONCLUSIONS. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28-including constructs should be considered in mucosal vaccines to prevent HIV infection of the gastro-intestinal MLP via modulation of IgA-ASC. en_US
dc.description.sponsorship Istituto Superiore di Sanita' "Programma Nazionale di Ricerca sull' AIDS"; DG Right to Health and Solidarity Policy; EMPRO and AVIP EC WP6 Projects; Japan Health Science Foundation; National Institutes of Child Health and Human Development (HD 39611, HD 40777) en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.title The Mucosae-Associated Epithelial Chemokine (MEC/CCL28) Modulates Immunity in HIV Infection en_US
dc.type article en_US
dc.identifier.doi 10.1371/journal.pone.0000969 en_US
dc.identifier.pubmedid 17912348 en_US
dc.identifier.pmcid 1989139 en_US

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