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dc.contributor.authorHansen, Lorenen_US
dc.contributor.authorMariño-Ramírez, Leonardoen_US
dc.contributor.authorLandsman, Daviden_US
dc.date.accessioned2012-01-11T21:11:31Z
dc.date.available2012-01-11T21:11:31Z
dc.date.copyright2009en_US
dc.date.issued2010-01-04en_US
dc.identifier.citationHansen, Loren, Leonardo Mariño-Ramírez, David Landsman. "Many sequence-specific chromatin modifying protein-binding motifs show strong positional preferences for potential regulatory regions in the Saccharomyces cerevisiae genome" Nucleic Acids Research 38(6): 1772-1779. (2010)en_US
dc.identifier.issn1362-4962en_US
dc.identifier.urihttp://hdl.handle.net/2144/3209
dc.description.abstractInitiation and regulation of gene expression is critically dependent on the binding of transcriptional regulators, which is often temporal and position specific. Many transcriptional regulators recognize and bind specific DNA motifs. The length and degeneracy of these motifs results in their frequent occurrence within the genome, with only a small subset serving as actual binding sites. By occupying potential binding sites, nucleosome placement can specify which sequence motif is available for DNA-binding regulatory factors. Therefore, the specification of nucleosome placement to allow access to transcriptional regulators whenever and wherever required is critical. We show that many DNA-binding motifs in Saccharomyces cerevisiae show a strong positional preference to occur only in potential regulatory regions. Furthermore, using gene ontology enrichment tools, we demonstrate that proteins with binding motifs that show the strongest positional preference also have a tendency to have chromatin-modifying properties and functions. This suggests that some DNA-binding proteins may depend on the distribution of their binding motifs across the genome to assist in the determination of specificity. Since many of these DNA-binding proteins have chromatin remodeling properties, they can alter the local nucleosome structure to a more permissive and/or restrictive state, thereby assisting in determining DNA-binding protein specificity.en_US
dc.description.sponsorshipCORPOICA; Intramural Program of the National Library of Medicine; National Institutes of Healthen_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.rightsCopyright Hansen, Loren, Leonardo Mariño-Ramírez, David Landsman 2009. Published by Oxford University Press.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.5en_US
dc.titleMany Sequence-Specific Chromatin Modifying Protein-Binding Motifs Show Strong Positional Preferences for Potential Regulatory Regions in the Saccharomyces Cerevisiae Genomeen_US
dc.typearticleen_US
dc.identifier.doi10.1093/nar/gkp1195en_US
dc.identifier.pubmedid20047965en_US
dc.identifier.pmcid2847247en_US


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Copyright Hansen, Loren, Leonardo Mariño-Ramírez, David Landsman 2009. Published by Oxford University Press.
Except where otherwise noted, this item's license is described as Copyright Hansen, Loren, Leonardo Mariño-Ramírez, David Landsman 2009. Published by Oxford University Press.