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dc.contributor.authorGuo, Chao-Yuen_US
dc.date.accessioned2012-01-11T17:18:24Z
dc.date.available2012-01-11T17:18:24Z
dc.date.copyright2007en_US
dc.date.issued2007-12-18en_US
dc.identifier.citationGuo, Chao-Yu. "The impact of complex informative missingness on the validity of the transmission/disequilibrium test (TDT)" BMC Proceedings 1(Suppl 1):S26. (2007)en_US
dc.identifier.issn1753-6561en_US
dc.identifier.urihttp://hdl.handle.net/2144/3145
dc.description.abstractThe transmission/disequilibrium test was introduced to test for linkage and association between a marker and a putative disease locus using case-parent triads. Several extensions have been proposed to accommodate incomplete triads. Some strategies assumed that parental genotypes were missing completely at random and some methods allowed informative missingness for parental genotypes. However, the above tests assumed that offspring genotypes were missing completely at random and concluded that the transmission/disequilibrium test remained a valid test by excluding incomplete triads from the analysis. In this article, the conditional distribution of ascertained triads allowing informative missingness for offspring genotypes, as well as their parental genotypes, was derived and several tests under such scenarios were evaluated. In simulations, independent triads from the Genetic Analysis Workshop 15 simulated data (Problem 3) was ascertained. When offspring genotypes were missing informatively, simulation results revealed inflated type I error and/or reduced power for the transmission/disequilibrium test excluding incomplete triads.en_US
dc.description.sponsorshipNational Heart, Lung and Blood Institute's Framingham Heart Study (N01-HC-25195)en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2007 Guo; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleThe impact of complex informative missingness on the validity of the transmission/disequilibrium test (TDT)en_US
dc.typearticleen_US
dc.identifier.pubmedid18466523en_US
dc.identifier.pmcid2367473en_US


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Copyright 2007 Guo; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2007 Guo; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.