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dc.contributor.authorLiu, Chunyuen_US
dc.contributor.authorCupples, L Adrienneen_US
dc.contributor.authorDupuis, Joséeen_US
dc.date.accessioned2012-01-11T15:51:12Z
dc.date.available2012-01-11T15:51:12Z
dc.date.copyright2005en_US
dc.date.issued2005-12-30en_US
dc.identifier.citationLiu, Chunyu, L Adrienne Cupples, Josée Dupuis. "Comparisons of case-selection approaches based on allele sharing and/or disease severity index: application to the GAW14 simulated data" BMC Genetics 6(Suppl 1):S103. (2005)en_US
dc.identifier.issn1471-2156en_US
dc.identifier.urihttp://hdl.handle.net/2144/3076
dc.description.abstractFor mapping complex disease traits, linkage studies are often followed by a case-control association strategy in order to identify disease-associated genes/single-nucleotide polymorphisms (SNPs). Substantial efforts are required in selecting the most informative cases from a large collection of affected individuals in order to maximize the power of the study, while taking into consideration study cost. In this article, we applied and extended three case-selection strategies that use allele-sharing information method for families with multiple affected offspring to select most informative cases using additional information on disease severity. Our results revealed that most significant associations, as measured by the lowest p-values, were obtained from a strategy that selected a case with the most allele sharing with other affected sibs from linked families ("linked-best"), despite reduction in sample size resulting from discarding unlinked families. Moreover, information on disease severity appears to be useful to improve the ability to detect associations between markers and disease loci.en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2005 Liu et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleComparisons of Case-Selection Approaches Based on Allele Sharing and/or Disease Severity Index: Application to the GAW14 Simulated Dataen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1471-2156-6-S1-S103en_US
dc.identifier.pubmedid16451559en_US
dc.identifier.pmcid1866836en_US


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Copyright 2005 Liu et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2005 Liu et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.