Show simple item record

dc.contributor.authorZheng, Yuen_US
dc.contributor.authorRoberts, Richard Jen_US
dc.contributor.authorKasif, Simonen_US
dc.date.accessioned2012-01-11T00:40:41Z
dc.date.available2012-01-11T00:40:41Z
dc.date.issued2004-4-13en_US
dc.identifier.citationZheng, Yu, Richard J Roberts, Simon Kasif. "Segmentally Variable Genes:A New Perspective on Adaptation" PLoS Biology 2(4): 0452-0464. (2004)en_US
dc.identifier.issn1545-7885en_US
dc.identifier.urihttp://hdl.handle.net/2144/3038
dc.description.abstractGenomic sequence variation is the hallmark of life and is key to understanding diversity and adaptation among the numerous microorganisms on earth. Analysis of the sequenced microbial genomes suggests that genes are evolving at many different rates. We have attempted to derive a new classification of genes into three broad categories: lineage-specific genes that evolve rapidly and appear unique to individual species or strains; highly conserved genes that frequently perform housekeeping functions; and partially variable genes that contain highly variable regions, at least 70 amino acids long, interspersed among well-conserved regions. The latter we term segmentally variable genes (SVGs), and we suggest that they are especially interesting targets for biochemical studies. Among these genes are ones necessary to deal with the environment, including genes involved in host–pathogen interactions, defense mechanisms, and intracellular responses to internal and environmental changes. For the most part, the detailed function of these variable regions remains unknown. We propose that they are likely to perform important binding functions responsible for protein–protein, protein–nucleic acid, or protein–small molecule interactions. Discerning their function and identifying their binding partners may offer biologists new insights into the basic mechanisms of adaptation, context-dependent evolution, and the interaction between microbes and their environment. Segmentally variable genes show a mosaic pattern of one or more rapidly evolving, variable regions. Discerning their function may provide new insights into the forces that shape genome diversity and adaptationen_US
dc.description.sponsorshipNational Science Foundation (998088, 0239435)en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.titleSegmentally Variable Genes: A New Perspective on Adaptationen_US
dc.typearticleen_US
dc.identifier.doi10.1371/journal.pbio.0020081en_US
dc.identifier.pubmedid15094797en_US
dc.identifier.pmcid387263en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record