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dc.contributor.authorLi, Zhengen_US
dc.contributor.authorChan, Christinaen_US
dc.date.accessioned2012-01-11T00:37:40Z
dc.date.available2012-01-11T00:37:40Z
dc.date.copyright2009en_US
dc.date.issued2009-3-10en_US
dc.identifier.citationLi, Zheng, Christina Chan. "Systems biology for identifying liver toxicity pathways" BMC Proceedings 3(Suppl 2):S2. (2009)en_US
dc.identifier.issn1753-6561en_US
dc.identifier.urihttp://hdl.handle.net/2144/3005
dc.description.abstractDrug-induced liver toxicity is one of the leading causes of acute liver failure in the United States, exceeding all other causes combined. The objective of this paper is to describe systems biology methods for identifying pathways involved in liver toxicity induced by free fatty acids (FFA) and tumor necrosis factor (TNF)-α in human hepatoblastoma cells (HepG2/C3A). Systems biology approaches were developed to integrate multi-level data, i.e., gene expression, metabolite profile, toxicity measurements and a priori knowledge to identify gene targets for modulating liver toxicity. Targets that modulate liver toxicity, in vitro, were computationally predicted and some targets were experimentally validated.en_US
dc.description.sponsorshipNational Science Foundation (BES 0425821, SBIR 0610784); National Institute of Health (R01GM079688, R21RR024439, R21CA126136); Whitaker Foundationen_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2009 Li and Chan; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleSystems Biology for Identifying Liver Toxicity Pathwaysen_US
dc.typearticleen_US
dc.identifier.pubmedid19278558en_US
dc.identifier.pmcid2654485en_US


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Copyright 2009 Li and Chan; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2009 Li and Chan; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.