VisANT: An Online Visualization and Analysis Tool for Biological Interaction Data


Show simple item record Hu, Zhenjun en_US Mellor, Joseph en_US Wu, Jie en_US DeLisi, Charles en_US 2012-01-11T00:37:38Z 2012-01-11T00:37:38Z 2004-2-19 en_US
dc.identifier.citation Hu, Zhenjun, Joseph Mellor, Jie Wu, Charles DeLisi. "VisANT: an online visualization and analysis tool for biological interaction data" BMC Bioinformatics 5:17. (2004) en_US
dc.identifier.issn 1471-2105 en_US
dc.description.abstract BACKGROUND. New techniques for determining relationships between biomolecules of all types – genes, proteins, noncoding DNA, metabolites and small molecules – are now making a substantial contribution to the widely discussed explosion of facts about the cell. The data generated by these techniques promote a picture of the cell as an interconnected information network, with molecular components linked with one another in topologies that can encode and represent many features of cellular function. This networked view of biology brings the potential for systematic understanding of living molecular systems. RESULTS. We present VisANT, an application for integrating biomolecular interaction data into a cohesive, graphical interface. This software features a multi-tiered architecture for data flexibility, separating back-end modules for data retrieval from a front-end visualization and analysis package. VisANT is a freely available, open-source tool for researchers, and offers an online interface for a large range of published data sets on biomolecular interactions, including those entered by users. This system is integrated with standard databases for organized annotation, including GenBank, KEGG and SwissProt. VisANT is a Java-based, platform-independent tool suitable for a wide range of biological applications, including studies of pathways, gene regulation and systems biology. CONCLUSION. VisANT has been developed to provide interactive visual mining of biological interaction data sets. The new software provides a general tool for mining and visualizing such data in the context of sequence, pathway, structure, and associated annotations. Interaction and predicted association data can be combined, overlaid, manipulated and analyzed using a variety of built-in functions. VisANT is available at. en_US
dc.description.sponsorship National Institutes of Health (IP20GM066401-01) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.title VisANT: An Online Visualization and Analysis Tool for Biological Interaction Data en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2105-5-17 en_US
dc.identifier.pubmedid 15028117 en_US
dc.identifier.pmcid 368431 en_US

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