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dc.contributor.authorMogues, Tirsiten_US
dc.contributor.authorEtzerodt, Michaelen_US
dc.contributor.authorHall, Crystalen_US
dc.contributor.authorEngelich, Georgen_US
dc.contributor.authorGraversen, Jonas H.en_US
dc.contributor.authorHartshorn, Kevan L.en_US
dc.date.accessioned2012-01-09T20:56:59Z
dc.date.available2012-01-09T20:56:59Z
dc.date.issued2004en_US
dc.identifier.citationMogues, Tirsit, Michael Etzerodt, Crystal Hall, Georg Engelich, Jonas H. Graversen, Kevan L. Hartshorn. "Tetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activity" Journal of Biomedicine and Biotechnology 2004(2): 73-78.en_US
dc.identifier.issn1110-7251en_US
dc.identifier.urihttp://hdl.handle.net/2144/2921
dc.description.abstractTetranectin is a plasminogen kringle 4 domain-binding protein present in plasma and various tissue locations. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis. A possible mechanism through which tetranectin could influence cancer progression is by altering activities of plasminogen or the plasminogen fragment, angiostatin. Tetranectin was found to bind to the kringle 1-4 form of angiostatin (ASTK1-4). In addition, tetranectin inhibited binding of plasminogen or ASTK1-4 to extracellular matrix (ECM) deposited by endothelial cells. Finally, tetranectin partially counteracted the ability of ASTK1-4 to inhibit proliferation of endothelial cells. This latter effect of tetranectin was specific for ASTK1-4 since it did not counteract the antiproliferative activities of the kringle 1-3 form of angiostatin (ASTK1-3) or endostatin. These findings suggest that tetranectin may modulate angiogenesis through interactions with AST.en_US
dc.description.sponsorshipNational Institutes of Health (HL69031)en_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.titleTetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activityen_US
dc.typearticleen_US
dc.identifier.doi10.1155/S1110724304307096en_US
dc.identifier.pubmedid15240916en_US
dc.identifier.pmcid548802en_US


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