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dc.contributor.authorStead, Lesley Aen_US
dc.contributor.authorLash, Timothy Len_US
dc.contributor.authorSobieraj, Jerome Een_US
dc.contributor.authorChi, Dorcas Den_US
dc.contributor.authorWestrup, Jennifer Len_US
dc.contributor.authorCharlot, Marjoryen_US
dc.contributor.authorBlanchard, Rita Aen_US
dc.contributor.authorLee, John Cen_US
dc.contributor.authorKing, Thomas Cen_US
dc.contributor.authorRosenberg, Carol Len_US
dc.date.accessioned2012-01-09T20:54:52Z
dc.date.available2012-01-09T20:54:52Z
dc.date.copyright2009en_US
dc.date.issued2009-3-25en_US
dc.identifier.citationStead, Lesley A, Timothy L Lash, Jerome E Sobieraj, Dorcas D Chi, Jennifer L Westrup, Marjory Charlot, Rita A Blanchard, John C Lee, Thomas C King, Carol L Rosenberg. "Triple-negative breast cancers are increased in black women regardless of age or body mass index" Breast Cancer Research: BCR 11(2):R18. (2009)en_US
dc.identifier.issn1465-542Xen_US
dc.identifier.urihttp://hdl.handle.net/2144/2914
dc.description.abstractINTRODUCTION. We investigated clinical and pathologic features of breast cancers (BC) in an unselected series of patients diagnosed in a tertiary care hospital serving a diverse population. We focused on triple-negative (Tneg) tumours (oestrogen receptor (ER), progesterone receptor (PR) and HER2 negative), which are associated with poor prognosis. METHODS. We identified female patients with invasive BC diagnosed between 1998 and 2006, with data available on tumor grade, stage, ER, PR and HER2 status, and patient age, body mass index (BMI) and self-identified racial/ethnic group. We determined associations between patient and tumour characteristics using contingency tables and multivariate logistic regression. RESULTS. 415 cases were identified. Patients were racially and ethnically diverse (born in 44 countries, 36% white, 43% black, 10% Hispanic and 11% other). 47% were obese (BMI > 30 kg/m2). 72% of tumours were ER+ and/or PR+, 20% were Tneg and 13% were HER2+. The odds of having a Tneg tumour were 3-fold higher (95% CI 1.6, 5.5; p = 0.0001) in black compared with white women. Tneg tumours were equally common in black women diagnosed before and after age 50 (31% vs 29%; p = NS), and who were obese and non-obese (29% vs 31%; p = NS). Considering all patients, as BMI increased, the proportion of Tneg tumours decreased (p = 0.08). CONCLUSIONS. Black women of diverse background have 3-fold more Tneg tumours than non-black women, regardless of age and BMI. Other factors must determine tumour subtype. The higher prevalence of Tneg tumours in black women in all age and weight categories likely contributes to black women's unfavorable breast cancer prognosis.en_US
dc.description.sponsorshipLaPann Fund; Research Enhancement Funden_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2009 Stead et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleTriple-Negative Breast Cancers are Increased in Black Women Regardless of Age or Body Mass Indexen_US
dc.typearticleen_US
dc.identifier.doi10.1186/bcr2242en_US
dc.identifier.pubmedid19320967en_US
dc.identifier.pmcid2688946en_US


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Copyright 2009 Stead et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2009 Stead et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.