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dc.contributor.authorDeng, Lingyi Lynnen_US
dc.contributor.authorAlexander, Alice A.en_US
dc.contributor.authorLei, Sijinen_US
dc.contributor.authorAnderson, John S.en_US
dc.date.accessioned2012-01-09T20:54:52Z
dc.date.available2012-01-09T20:54:52Z
dc.date.copyright2010en_US
dc.date.issued2010-4-6en_US
dc.identifier.citationDeng, Lingyi Lynn, Alice A. Alexander, Sijin Lei, John S. Anderson. "The Cell Wall Teichuronic Acid Synthetase (TUAS) Is an Enzyme Complex Located in the Cytoplasmic Membrane of Micrococcus luteus" Biochemistry Research International 2010:395758. (2010)en_US
dc.identifier.issn2090-2255en_US
dc.identifier.urihttp://hdl.handle.net/2144/2913
dc.description.abstractThe cell wall teichuronic acid (TUA) of Micrococcus luteus is a long-chain polysaccharide composed of disaccharide repeating units [-4-β-D-ManNAcAp-(1→6)α-D-Glcp−1-]n, which is covalently anchored to the peptidoglycan on the inner cell wall and extended to the outer surface of the cell envelope. An enzyme complex responsible for the TUA chain biosynthesis was purified and characterized. The 440kDa enzyme complex, named teichuronic acid synthetase (TUAS), is an octomer composed of two kinds of glycosyltransferases, Glucosyltransferase, and ManNAcA-transferase, which is capable of catalyzing the transfer of disaccharide glycosyl residues containing both glucose and the N-acetylmannosaminuronic acid residues. TUAS displays hydrophobic properties and is found primarily associated with the cytoplasmic membrane. The purified TUAS contains carotinoids and lipids. TUAS activity is diminished by phospholipase digestion. We propose that TUAS serves as a multitasking polysaccharide assembling station on the bacterial membrane.en_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (Public Health Service Grants AI-08295); American Lung Association (RG-107-N)en_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rightsCopyright 2010 Lingyi Lynn Deng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.titleThe Cell Wall Teichuronic Acid Synthetase (TUAS) Is an Enzyme Complex Located in the Cytoplasmic Membrane of Micrococcus luteusen_US
dc.typearticleen_US
dc.identifier.doi10.1155/2010/395758en_US
dc.identifier.pubmedid21188072en_US
dc.identifier.pmcid3005890en_US


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