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dc.contributor.authorGuo, Chao-Yuen_US
dc.contributor.authorCui, Jingen_US
dc.contributor.authorCupples, L Adrienneen_US
dc.date.accessioned2012-01-09T20:53:14Z
dc.date.available2012-01-09T20:53:14Z
dc.date.copyright2005en_US
dc.date.issued2005-12-30en_US
dc.identifier.citationGuo, Chao-Yu, Jing Cui, L Adrienne Cupples. "Impact of non-ignorable missingness on genetic tests of linkage and/or association using case-parent trios" BMC Genetics 6(Suppl 1):S90. (2005)en_US
dc.identifier.issn1471-2156en_US
dc.identifier.urihttp://hdl.handle.net/2144/2894
dc.description.abstractThe transmission/disequilibrium test was introduced to test for linkage disequilibrium between a marker and a putative disease locus using case-parent trios. However, parental genotypes may be incomplete in such a study. When parental information is non-randomly missing, due, for example, to death from the disease under study, the impact on type I error and power under dominant and recessive disease models has been reported. In this paper, we examine non-ignorable missingness by assigning missing values to the genotypes of affected parents. We used unrelated case-parent trios in the Genetic Analysis Workshop 14 simulated data for the Danacaa population. Our computer simulations revealed that the type I error of these tests using incomplete trios was not inflated over the nominal level under either recessive or dominant disease models. However, the power of these tests appears to be inflated over the complete information case due to an excess of heterozygous parents in dyads.en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2005 Guo et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleImpact of Non-Ignorable Missingness on Genetic Tests of Linkage and/or Association Using Case-Parent Triosen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1471-2156-6-S1-S90en_US
dc.identifier.pubmedid16451706en_US
dc.identifier.pmcid1866689en_US


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Copyright 2005 Guo et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2005 Guo et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.