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dc.contributor.authorYang, Qiongen_US
dc.contributor.authorChazaro, Irmarieen_US
dc.contributor.authorCui, Jingen_US
dc.contributor.authorGuo, Chao-Yuen_US
dc.contributor.authorDemissie, Serkalemen_US
dc.contributor.authorLarson, Martinen_US
dc.contributor.authorAtwood, Larry Den_US
dc.contributor.authorCupples, L Adrienneen_US
dc.contributor.authorDeStefano, Anita Len_US
dc.date.accessioned2012-01-09T20:53:14Z
dc.date.available2012-01-09T20:53:14Z
dc.date.copyright2003en_US
dc.date.issued2003-12-31en_US
dc.identifier.citationYang, Qiong, Irmarie Chazaro, Jing Cui, Chao-Yu Guo, Serkalem Demissie, Martin Larson, Larry D Atwood, L Adrienne Cupples, Anita L DeStefano. "Genetic analyses of longitudinal phenotype data: a comparison of univariate methods and a multivariate approach" BMC Genetics 4(Suppl 1):S29. (2003)en_US
dc.identifier.issn1471-2156en_US
dc.identifier.urihttp://hdl.handle.net/2144/2892
dc.description.abstractBACKGROUND. We explored three approaches to heritability and linkage analyses of longitudinal total cholesterol levels (CHOL) in the Genetic Analysis Workshop 13 simulated data without knowing the answers. The first two were univariate approaches and used 1) baseline measure at exam one or 2) summary measures such as mean and slope from multiple exams. The third method was a multivariate approach that directly models multiple measurements on a subject. A variance components model (SOLAR) was employed in the univariate approaches. A mixed regression model with polynomials was employed in the multivariate approach and implemented in SAS/IML. RESULTS. Using the baseline measure at exam 1, we detected all baseline or slope genes contributing a substantial amount (0.08) of variance (LOD > 3). Compared to the baseline measure, the mean measures yielded slightly higher LOD at the slope genes, and a lower LOD at the baseline genes. The slope measure produced a somewhat lower LOD for the slope gene than did the mean measure. Descriptive information on the pattern of changes in gene effects with age was estimated for three linked loci by the third approach. CONCLUSION. We found simple univariate methods may be effective to detect genes affecting longitudinal phenotypes but may not fully reveal temporal trends in gene effects. The relative efficiency of the univariate methods to detect genes depends heavily on the underlying model. Compared with the univariate approaches, the multivariate approach provided more information on temporal trends in gene effects at the cost of more complicated modelling and more intense computations.en_US
dc.description.sponsorshipNational Institutes of Health (P50-HL55001)en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2003 Yang et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleGenetic Analyses of Longitudinal Phenotype Data: A Comparison of Univariate Methods and a Multivariate Approachen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1471-2156-4-S1-S29en_US
dc.identifier.pubmedid14975097en_US
dc.identifier.pmcid1866464en_US


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Copyright 2003 Yang et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2003 Yang et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.