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dc.contributor.authorCole, J. Alexanderen_US
dc.contributor.authorRothman, Kenneth J.en_US
dc.contributor.authorCabral, Howard J.en_US
dc.contributor.authorZhang, Yuqingen_US
dc.contributor.authorFarraye, Francis A.en_US
dc.date.accessioned2012-01-09T20:53:13Z
dc.date.available2012-01-09T20:53:13Z
dc.date.copyright2006
dc.date.issued2006-9-28
dc.identifier.citationCole, J Alexander, Kenneth J Rothman, Howard J Cabral, Yuqing Zhang, Francis A Farraye. "Migraine, fibromyalgia, and depression among people with IBS: a prevalence study" BMC Gastroenterology 6:26. (2006)
dc.identifier.issn1471-230X
dc.identifier.urihttp://hdl.handle.net/2144/2888
dc.description.abstractBACKGROUND. Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people with and without IBS. METHODS. The source of data was a large U.S. health plan from January 1, 1996 though June 30, 2002. We identified all people with a medical claim associated with an ICD-9 code for IBS. A non-IBS cohort was a random sample of people with an ICD-9 code for routine medical care. In the cohorts, we identified all claims for migraine, depression, and fibromyalgia. We estimated the prevalence odds ratios (PORs) of each of the three conditions using the Mantel-Haenszel method. We conducted quantitative sensitivity analyses to quantify the impact of residual confounding and in differential outcome identification. RESULTS. We identified 97,593 people in the IBS cohort, and a random sample of 27,402 people to compose the non-IBS comparison cohort. With adjustment, there was a 60% higher odds in the IBS cohort of having any one of the three disorders relative to the comparison cohort (POR 1.6, 95% CI 1.5 – 1.7). There was a 40% higher odds of depression in the IBS cohort (POR 1.4, 95% CI 1.3 – 1.4). The PORs for fibromyalgia and migraine were similar (POR for fibromyalgia 1.8, 95% CI 1.7 – 1.9; POR for migraine 1.6, 95% CI 1.4 – 1.7). Differential prevalence of an unmeasured confounder, or imperfect sensitivity or specificity of outcome detection would have impacted the observed results. CONCLUSION. People in the IBS cohort had a 40% to 80% higher prevalence odds of migraine, fibromyalgia, and depression.en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2006 Cole et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.titleMigraine, Fibromyalgia, and Depression among People with IBS: A Prevalence Studyen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1471-230X-6-26
dc.identifier.pubmedid17007634
dc.identifier.pmcid1592499


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Copyright 2006 Cole et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2006 Cole et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.