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dc.contributor.authorKalichman, Leoniden_US
dc.contributor.authorZhang, Yuqingen_US
dc.contributor.authorNiu, Jingboen_US
dc.contributor.authorGoggins, Joyceen_US
dc.contributor.authorGale, Danielen_US
dc.contributor.authorZhu, Yanyanen_US
dc.contributor.authorFelson, David Ten_US
dc.contributor.authorHunter, David Jen_US
dc.date.accessioned2012-01-09T20:51:29Z
dc.date.available2012-01-09T20:51:29Z
dc.date.copyright2007en_US
dc.date.issued2007-3-7en_US
dc.identifier.citationKalichman, Leonid, Yuqing Zhang, Jingbo Niu, Joyce Goggins, Daniel Gale, Yanyan Zhu, David T Felson, David J Hunter. "The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis" Arthritis Research & Therapy 9(2):R26. (2007)en_US
dc.identifier.issn1478-6362en_US
dc.identifier.urihttp://hdl.handle.net/2144/2874
dc.description.abstractThe aim of our study was to evaluate the association between patellar alignment by using magnetic resonance imaging images and radiographic manifestations of patello-femoral osteoarthritis (OA). Subjects were recruited to participate in a natural history study of symptomatic knee OA. We examined the relation of patellar alignment in the sagittal plane (patellar length ratio (PLR)) and the transverse plane (sulcus angle (SA), lateral patellar tilt angle (LPTA), and bisect offset (BO)) to radiographic features of patello-femoral OA, namely joint space narrowing and patellar osteophytes, using a proportional odds logistic regression model while adjusting for age, sex, and bone mass index (BMI). The study sample consisted of 126 males (average age 68.0 years, BMI 31.2) and 87 females (average age 64.7 years, BMI 31.6), 75% of whom had tibiofemoral OA (a Kellgren-Lawrence score of 2 or more). PLR showed a statistically significant association with joint space narrowing and osteophytosis in the lateral compartment. SA showed significant association with medial joint space narrowing and with lateral and medial patellar osteophytosis. LPTA and BO showed significant association with both radiographic indices of the lateral compartment. Clear linear trends were found in association between PLR, LPTA and BO, and with outcomes associated with lateral patello-femoral OA. SA, LPTA, and BO showed linear trends of association with medial joint space narrowing. Results of our study clearly suggest the association between indices of patellar alignment and such features of patello-femoral OA as osteophytosis and joint space narrowing. Additional studies will be required to establish the normal and abnormal ranges of patellar alignment indices and their longitudinal relation to patello-femoral OA.en_US
dc.description.sponsorshipNational Institutes of Health (AR47785); Arthritis Foundation (Osteoarthritis Biomarkers Grant); Arthritis Foundation Clinical Sciences Granten_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2007 Kalichman et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleThe Association between Patellar Alignment on Magnetic Resonance Imaging and Radiographic Manifestations of Knee Osteoarthritisen_US
dc.typearticleen_US
dc.identifier.doi10.1186/ar2138en_US
dc.identifier.pubmedid17343731en_US
dc.identifier.pmcid1906802en_US


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Copyright 2007 Kalichman et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2007 Kalichman et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.