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dc.contributor.authorPeter, Angela K.en_US
dc.contributor.authorKo, Christopher Y.en_US
dc.contributor.authorKim, Michelle H.en_US
dc.contributor.authorHsu, Nigelen_US
dc.contributor.authorOuchi, Noriyukien_US
dc.contributor.authorRhie, Suhnen_US
dc.contributor.authorIzumiya, Yasuhiroen_US
dc.contributor.authorZeng, Lingen_US
dc.contributor.authorWalsh, Kennethen_US
dc.contributor.authorCrosbie, Rachelle H.en_US
dc.date.accessioned2012-01-09T15:42:39Z
dc.date.available2012-01-09T15:42:39Z
dc.date.issued2008-11-04en_US
dc.identifier.citationPeter, Angela K., Christopher Y. Ko, Michelle H. Kim, Nigel Hsu, Noriyuki Ouchi, Suhn Rhie, Yasuhiro Izumiya, Ling Zeng, Kenneth Walsh, Rachelle H. Crosbie. "Myogenic Akt Signaling Upregulates the Utrophin-Glycoprotein Complex and Promotes Sarcolemma Stability in Muscular Dystrophy" Human Molecular Genetics 18(2): 318-327. (2008)en_US
dc.identifier.issn1460-2083en_US
dc.identifier.urihttp://hdl.handle.net/2144/2836
dc.description.abstractDuchenne muscular dystrophy is caused by dystrophin mutations that lead to structural instability of the sarcolemma membrane, myofiber degeneration/regeneration and progressive muscle wasting. Here we show that myogenic Akt signaling in mouse models of dystrophy promotes increased expression of utrophin, which replaces the function of dystrophin thereby preventing sarcolemma damage and muscle wasting. In contrast to previous suggestions that increased Akt in dystrophy was a secondary consequence of pathology, our findings demonstrate a pivotal role for this signaling pathway such that modulation of Akt can significantly affect disease outcome by amplification of existing, physiological compensatory mechanisms.en_US
dc.description.sponsorshipNational Institutes of Health (T32 GM65823, T32 GM65823); Harold and Lillian Kraus Americal Heart Pre-doctoral Fellowship; Training in Cardiovascular Physiology and Pharmacology Training Grant(5T32HL007444-27); American Heart Association; Muscular Dystrophy Association (MDA3704)en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.titleMyogenic Akt Signaling Upregulates the Utrophin-Glycoprotein Complex and Promotes Sarcolemma Stability in Muscular Dystrophyen_US
dc.typearticleen_US
dc.identifier.doi10.1093/hmg/ddn358en_US
dc.identifier.pubmedid18986978en_US
dc.identifier.pmcid2638781en_US


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