Association of Exposure to Phthalates with Endometriosis and Uterine Leiomyomata: Findings from NHANES, 1999-2004


Show simple item record Weuve, Jennifer en_US Hauser, Russ en_US Calafat, Antonia M. en_US Missmer, Stacey A. en_US Wise, Lauren A. en_US 2012-01-09T15:42:14Z 2012-01-09T15:42:14Z 2010-06 en_US
dc.identifier.citation Weuve, Jennifer, Russ Hauser, Antonia M. Calafat, Stacey A. Missmer, Lauren A. Wise. "Association of Exposure to Phthalates with Endometriosis and Uterine Leiomyomata: Findings from NHANES, 1999-2004" Environmental Health Perspectives 118(6): 825-832. (2010) en_US
dc.identifier.issn 1552-9924 en_US
dc.description.abstract BACKGROUND. Phthalates are ubiquitous chemicals used in consumer products. Some phthalates are reproductive toxicants in experimental animals, but human data are limited. OBJECTIVE. We conducted a cross-sectional study of urinary phthalate metabolite concentrations in relation to self-reported history of endometriosis and uterine leiomyomata among 1,227 women 20-54 years of age from three cycles of the National Health and Nutrition Examination Survey (NHANES), 1999-2004. METHODS. We examined four phthalate metabolites: mono(2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MBP), monoethyl phthalate (MEP), and monobenzyl phthalate (MBzP). From the last two NHANES cycles, we also examined mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP). We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for potential confounders. RESULTS. Eighty-seven (7%) and 151 (12%) women reported diagnoses of endometriosis and leiomyomata, respectively. The ORs comparing the highest versus lowest three quartiles of urinary MBP were 1.36 (95% CI, 0.77-2.41) for endometriosis, 1.56 (95% CI, 0.93-2.61) for leiomyomata, and 1.71 (95% CI, 1.07-2.75) for both conditions combined. The corresponding ORs for MEHP were 0.44 (95% CI, 0.19-1.02) for endometriosis, 0.63 (95% CI, 0.35-1.12) for leiomyomata, and 0.59 (95% CI, 0.37-0.95) for both conditions combined. Findings for MEHHP and MEOHP agreed with findings for MEHP with respect to endometriosis only. We observed null associations for MEP and MBzP. Associations were similar when we excluded women diagnosed > 7 years before their NHANES evaluation. CONCLUSION. The positive associations for MBP and inverse associations for MEHP in relation to endometriosis and leiomyomata warrant investigation in prospective studies. en_US
dc.language.iso en en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.rights This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. en_US
dc.subject Dibutyl phthalate en_US
dc.subject Di(2-ethylhexyl) phthalate en_US
dc.subject Endometriosis en_US
dc.subject Leiomyomata en_US
dc.subject Monobenzyl phthalate en_US
dc.subject Monobutyl phthalate en_US
dc.subject Monoethyl phthalate en_US
dc.subject Mono(2-ethyl-5-hydroxyhexyl) phthalate en_US
dc.subject Mono(2-ethyl-5-oxohexyl) phthalate en_US
dc.subject Mono(2-ethylhexyl) phthalate en_US
dc.title Association of Exposure to Phthalates with Endometriosis and Uterine Leiomyomata: Findings from NHANES, 1999-2004 en_US
dc.type article en_US
dc.identifier.doi 10.1289/ehp.0901543 en_US
dc.identifier.pubmedid 20185384 en_US
dc.identifier.pmcid 2898860 en_US

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