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dc.contributor.authorWeuve, Jenniferen_US
dc.contributor.authorHauser, Russen_US
dc.contributor.authorCalafat, Antonia M.en_US
dc.contributor.authorMissmer, Stacey A.en_US
dc.contributor.authorWise, Lauren A.en_US
dc.date.accessioned2012-01-09T15:42:14Z
dc.date.available2012-01-09T15:42:14Z
dc.date.issued2010-06en_US
dc.identifier.citationWeuve, Jennifer, Russ Hauser, Antonia M. Calafat, Stacey A. Missmer, Lauren A. Wise. "Association of Exposure to Phthalates with Endometriosis and Uterine Leiomyomata: Findings from NHANES, 1999-2004" Environmental Health Perspectives 118(6): 825-832. (2010)en_US
dc.identifier.issn1552-9924en_US
dc.identifier.urihttp://hdl.handle.net/2144/2835
dc.description.abstractBACKGROUND. Phthalates are ubiquitous chemicals used in consumer products. Some phthalates are reproductive toxicants in experimental animals, but human data are limited. OBJECTIVE. We conducted a cross-sectional study of urinary phthalate metabolite concentrations in relation to self-reported history of endometriosis and uterine leiomyomata among 1,227 women 20-54 years of age from three cycles of the National Health and Nutrition Examination Survey (NHANES), 1999-2004. METHODS. We examined four phthalate metabolites: mono(2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MBP), monoethyl phthalate (MEP), and monobenzyl phthalate (MBzP). From the last two NHANES cycles, we also examined mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP). We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for potential confounders. RESULTS. Eighty-seven (7%) and 151 (12%) women reported diagnoses of endometriosis and leiomyomata, respectively. The ORs comparing the highest versus lowest three quartiles of urinary MBP were 1.36 (95% CI, 0.77-2.41) for endometriosis, 1.56 (95% CI, 0.93-2.61) for leiomyomata, and 1.71 (95% CI, 1.07-2.75) for both conditions combined. The corresponding ORs for MEHP were 0.44 (95% CI, 0.19-1.02) for endometriosis, 0.63 (95% CI, 0.35-1.12) for leiomyomata, and 0.59 (95% CI, 0.37-0.95) for both conditions combined. Findings for MEHHP and MEOHP agreed with findings for MEHP with respect to endometriosis only. We observed null associations for MEP and MBzP. Associations were similar when we excluded women diagnosed > 7 years before their NHANES evaluation. CONCLUSION. The positive associations for MBP and inverse associations for MEHP in relation to endometriosis and leiomyomata warrant investigation in prospective studies.en_US
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.rightsThis is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.en_US
dc.subjectDibutyl phthalateen_US
dc.subjectDi(2-ethylhexyl) phthalateen_US
dc.subjectEndometriosisen_US
dc.subjectLeiomyomataen_US
dc.subjectMonobenzyl phthalateen_US
dc.subjectMonobutyl phthalateen_US
dc.subjectMonoethyl phthalateen_US
dc.subjectMono(2-ethyl-5-hydroxyhexyl) phthalateen_US
dc.subjectMono(2-ethyl-5-oxohexyl) phthalateen_US
dc.subjectMono(2-ethylhexyl) phthalateen_US
dc.titleAssociation of Exposure to Phthalates with Endometriosis and Uterine Leiomyomata: Findings from NHANES, 1999-2004en_US
dc.typearticleen_US
dc.identifier.doi10.1289/ehp.0901543en_US
dc.identifier.pubmedid20185384en_US
dc.identifier.pmcid2898860en_US


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