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dc.contributor.authorRess, Daviden_US
dc.contributor.authorThompson, Jeffrey K.en_US
dc.contributor.authorRokers, Basen_US
dc.contributor.authorKhan, Reswanul K.en_US
dc.contributor.authorHuk, Alexander C.en_US
dc.date.accessioned2012-01-09T15:38:51Z
dc.date.available2012-01-09T15:38:51Z
dc.date.copyright2009en_US
dc.date.issued2009-06-29en_US
dc.identifier.citationRess, David, Jeffrey K. Thompson, Bas Rokers, Reswanul K. Khan, Alexander C. Huk. "A Model for Transient Oxygen Delivery in Cerebral Cortex" Frontiers in Neuroenergetics 1 (2009)en_US
dc.identifier.issn1662-6427en_US
dc.identifier.urihttp://hdl.handle.net/2144/2829
dc.description.abstractPopular hemodynamic brain imaging methods, such as blood oxygen-level dependent functional magnetic resonance imaging (BOLD fMRI), would benefit from a detailed understanding of the mechanisms by which oxygen is delivered to the cortex in response to brief periods of neural activity. Tissue oxygen responses in visual cortex following brief visual stimulation exhibit rich dynamics, including an early decrease in oxygen concentration, a subsequent large increase in concentration, and substantial late-time oscillations ("ringing"). We introduce a model that explains the full time-course of these observations made by Thompson et al. (2003). The model treats oxygen transport with a set of differential equations that include a combination of flow and diffusion in a three-compartment (intravascular, extravascular, and intracellular) system. Blood flow in this system is modeled using the impulse response of a lumped linear system that includes an inertive element; this provides a simple biophysical mechanism for the ringing. The model system is solved numerically to produce excellent fits to measurements of tissue oxygen. The results give insight into the dynamics of cerebral oxygen transfer, and can serve as the starting point to understand BOLD fMRI measurements.en_US
dc.language.isoenen_US
dc.publisherFrontiers Research Foundationen_US
dc.rightsCopyright 2009 Ress, Thompson, Rokers, Khan and Huk. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.en_US
dc.rights.urihttp://www.frontiersin.org/licenseagreementen_US
dc.subjectOxygen delivery and consumptionen_US
dc.subjectBrain activationen_US
dc.subjectCerebral hemodynamicsen_US
dc.titleA Model for Transient Oxygen Delivery in Cerebral Cortexen_US
dc.typearticleen_US
dc.identifier.doi10.3389/neuro.14.003.2009en_US
dc.identifier.pubmedid19597566en_US
dc.identifier.pmcid2709201en_US


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