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dc.contributor.authorWeisskopf, Marc G.en_US
dc.contributor.authorWeuve, Jenniferen_US
dc.contributor.authorNie, Huilingen_US
dc.contributor.authorSaint-Hilaire, Marie-Heleneen_US
dc.contributor.authorSudarsky, Lewisen_US
dc.contributor.authorSimon, David K.en_US
dc.contributor.authorHersh, Bonnieen_US
dc.contributor.authorSchwartz, Joelen_US
dc.contributor.authorWright, Robert O.en_US
dc.contributor.authorHu, Howarden_US
dc.date.accessioned2012-01-09T15:36:57Z
dc.date.available2012-01-09T15:36:57Z
dc.date.issued2010-11en_US
dc.identifier.citationWeisskopf, Marc G., Jennifer Weuve, Huiling Nie, Marie-Helene Saint-Hilaire, Lewis Sudarsky, David K. Simon, Bonnie Hersh, Joel Schwartz, Robert O. Wright, Howard Hu. "Association of Cumulative Lead Exposure with Parkinson's Disease" Environmental Health Perspectives 118 (11): 1609-1613. (2010)en_US
dc.identifier.issn1552-9924en_US
dc.identifier.urihttp://hdl.handle.net/2144/2823
dc.description.abstractBACKGROUND. Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson's disease (PD), but the only study that used bone lead, a biomarker of cumulative lead exposure, found a nonsignificant increase in risk of PD with increasing bone lead. OBJECTIVES. We sought to assess the association between bone lead and PD. METHODS. Bone lead concentrations were measured using 109Cd excited K-shell X-ray fluorescence from 330 PD patients (216 men, 114 women) and 308 controls (172 men, 136 women) recruited from four clinics for movement disorders and general-community cohorts. Adjusted odds ratios (ORs) for PD were calculated using logistic regression. RESULTS. The average age of cases and controls at bone lead measurement was 67 (SD = 10) and 69 (SD = 9) years of age, respectively. In primary analyses of cases and controls recruited from the same groups, compared with the lowest quartile of tibia lead, the OR for PD in the highest quartile was 3.21 [95% confidence interval (CI), 1.17-8.83]. Results were similar but slightly weaker in analyses restricted to cases and controls recruited from the movement disorders clinics only (fourth-quartile OR = 2.57; 95% CI, 1.11-5.93) or when we included controls recruited from sites that did not also contribute cases (fourth-quartile OR = 1.91; 95% CI, 1.01-3.60). We found no association with patella bone lead. CONCLUSIONS. These findings, using an objective biological marker of cumulative lead exposure among typical PD patients seen in our movement disorders clinics, strengthen the evidence that cumulative exposure to lead increases the risk of PD.en_US
dc.description.sponsorshipNational Institutes of Health (R01-ES010798, K01-ES01265)en_US
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.rightsThis is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.en_US
dc.subjectBiomarkersen_US
dc.subjectBone leaden_US
dc.subjectCase-control studyen_US
dc.subjectEpidemiologyen_US
dc.subjectHumansen_US
dc.subjectMetalsen_US
dc.subjectRisk factorsen_US
dc.titleAssociation of Cumulative Lead Exposure with Parkinson's Diseaseen_US
dc.typearticleen_US
dc.identifier.doi10.1289/ehp.1002339en_US
dc.identifier.pubmedid20807691en_US
dc.identifier.pmcid2974701en_US


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