Association of Cumulative Lead Exposure with Parkinson's Disease


Show simple item record Weisskopf, Marc G. en_US Weuve, Jennifer en_US Nie, Huiling en_US Saint-Hilaire, Marie-Helene en_US Sudarsky, Lewis en_US Simon, David K. en_US Hersh, Bonnie en_US Schwartz, Joel en_US Wright, Robert O. en_US Hu, Howard en_US 2012-01-09T15:36:57Z 2012-01-09T15:36:57Z 2010-11 en_US
dc.identifier.citation Weisskopf, Marc G., Jennifer Weuve, Huiling Nie, Marie-Helene Saint-Hilaire, Lewis Sudarsky, David K. Simon, Bonnie Hersh, Joel Schwartz, Robert O. Wright, Howard Hu. "Association of Cumulative Lead Exposure with Parkinson's Disease" Environmental Health Perspectives 118 (11): 1609-1613. (2010) en_US
dc.identifier.issn 1552-9924 en_US
dc.description.abstract BACKGROUND. Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson's disease (PD), but the only study that used bone lead, a biomarker of cumulative lead exposure, found a nonsignificant increase in risk of PD with increasing bone lead. OBJECTIVES. We sought to assess the association between bone lead and PD. METHODS. Bone lead concentrations were measured using 109Cd excited K-shell X-ray fluorescence from 330 PD patients (216 men, 114 women) and 308 controls (172 men, 136 women) recruited from four clinics for movement disorders and general-community cohorts. Adjusted odds ratios (ORs) for PD were calculated using logistic regression. RESULTS. The average age of cases and controls at bone lead measurement was 67 (SD = 10) and 69 (SD = 9) years of age, respectively. In primary analyses of cases and controls recruited from the same groups, compared with the lowest quartile of tibia lead, the OR for PD in the highest quartile was 3.21 [95% confidence interval (CI), 1.17-8.83]. Results were similar but slightly weaker in analyses restricted to cases and controls recruited from the movement disorders clinics only (fourth-quartile OR = 2.57; 95% CI, 1.11-5.93) or when we included controls recruited from sites that did not also contribute cases (fourth-quartile OR = 1.91; 95% CI, 1.01-3.60). We found no association with patella bone lead. CONCLUSIONS. These findings, using an objective biological marker of cumulative lead exposure among typical PD patients seen in our movement disorders clinics, strengthen the evidence that cumulative exposure to lead increases the risk of PD. en_US
dc.description.sponsorship National Institutes of Health (R01-ES010798, K01-ES01265) en_US
dc.language.iso en en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.rights This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. en_US
dc.subject Biomarkers en_US
dc.subject Bone lead en_US
dc.subject Case-control study en_US
dc.subject Epidemiology en_US
dc.subject Humans en_US
dc.subject Metals en_US
dc.subject Risk factors en_US
dc.title Association of Cumulative Lead Exposure with Parkinson's Disease en_US
dc.type article en_US
dc.identifier.doi 10.1289/ehp.1002339 en_US
dc.identifier.pubmedid 20807691 en_US
dc.identifier.pmcid 2974701 en_US

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