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dc.contributor.authorPeters, Junenette L.en_US
dc.contributor.authorWeisskopf, Marc G.en_US
dc.contributor.authorSpiro, Avronen_US
dc.contributor.authorSchwartz, Joelen_US
dc.contributor.authorSparrow, Daviden_US
dc.contributor.authorNie, Huilingen_US
dc.contributor.authorHu, Howarden_US
dc.contributor.authorWright, Robert O.en_US
dc.contributor.authorWright, Rosalind J.en_US
dc.date.accessioned2012-01-09T15:09:28Z
dc.date.available2012-01-09T15:09:28Z
dc.date.issued2010-04en_US
dc.identifier.citationPeters, Junenette L., Marc G. Weisskopf, Avron Spiro, Joel Schwartz, David Sparrow, Huiling Nie, Howard Hu, Robert O. Wright, Rosalind J. Wright. "Interaction of Stress, Lead Burden, and Age on Cognition in Older Men: The VA Normative Aging Study" Environmental Health Perspectives 118 (4): 505-510. (2009)en_US
dc.identifier.issn1552-9924en_US
dc.identifier.urihttp://hdl.handle.net/2144/2812
dc.description.abstractBACKGROUND. Low-level exposure to lead and to chronic stress may independently influence cognition. However, the modifying potential of psychosocial stress on the neurotoxicity of lead and their combined relationship to aging-associated decline have not been fully examined. OBJECTIVES. We examined the cross-sectional interaction between stress and lead exposure on Mini-Mental State Examination (MMSE) scores among 811 participants in the Normative Aging Study, a cohort of older U.S. men. METHODS. We used two self-reported measures of stress appraisal-a self-report of stress related to their most severe problem and the Perceived Stress Scale (PSS). Indices of lead exposure were blood lead and bone (tibia and patella) lead. RESULTS. Participants with higher self-reported stress had lower MMSE scores, which were adjusted for age, education, computer experience, English as a first language, smoking, and alcohol intake. In multivariable-adjusted tests for interaction, those with higher PSS scores had a 0.57-point lower (95% confidence interval, -0.90 to 0.24) MMSE score for a 2-fold increase in blood lead than did those with lower PSS scores. In addition, the combination of high PSS scores and high blood lead categories on one or both was associated with a 0.05-0.08 reduction on the MMSE for each year of age compared with those with low PSS score and blood lead level (p < 0.05). CONCLUSIONS. Psychological stress had an independent inverse association with cognition and also modified the relationship between lead exposure and cognitive performance among older men. Furthermore, high stress and lead together modified the association between age and cognition.en_US
dc.description.sponsorshipNational Institutes of Health (R01ES07821, R01HL080674, R01HL080674-02S1, R01ES013744, ES05257-06A1, P20MD000501, P42ES05947, ES03918-02); National Center for Research Resources General Clinical Research Center (M01RR02635); Leaves of Grass Foundation; United States Department of Veterans Affairsen_US
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.rightsThis is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.en_US
dc.subjectAgingen_US
dc.subjectBlooden_US
dc.subjectBoneen_US
dc.subjectLeaden_US
dc.subjectCognitionen_US
dc.subjectPsychological stressen_US
dc.titleInteraction of Stress, Lead Burden, and Age on Cognition in Older Men: The VA Normative Aging Studyen_US
dc.typearticleen_US
dc.identifier.doi10.1289/ehp.0901115en_US
dc.identifier.pubmedid20064786en_US
dc.identifier.pmcid2854727en_US


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