Show simple item record

dc.contributor.authorLinghu, Bolanen_US
dc.contributor.authorSnitkin, Evan S.en_US
dc.contributor.authorHu, Zhenjunen_US
dc.contributor.authorXia, Yuen_US
dc.contributor.authorDeLisi, Charlesen_US
dc.date.accessioned2012-01-09T14:44:43Z
dc.date.available2012-01-09T14:44:43Z
dc.date.copyright2009
dc.date.issued2009-09-03
dc.identifier.citationLinghu, Bolan, Evan S Snitkin, Zhenjun Hu, Yu Xia, Charles DeLisi. "Genome-Wide Prioritization of Disease Genes and Identification of Disease-Disease Associations from an Integrated Human Functional Linkage Network" Genome Biology 10(9):R91. (2009)
dc.identifier.issn1465-6914
dc.identifier.urihttp://hdl.handle.net/2144/2786
dc.description.abstractAn evidence-weighted functional-linkage network of human genes reveals associations among diseases that share no known disease genes and have dissimilar phenotypes. We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phenotypes, such as hypercholesterolemia and Alzheimer's disease. Many of these disease-disease associations are supported by epidemiology, but with no previous genetic basis. Such associations can drive novel hypotheses on molecular mechanisms of diseases and therapies.en_US
dc.description.sponsorshipNational Institutes of Health (R01 RR022971); RhRMA Foundation (Research Starter Grant)en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2009 Linghu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.titleGenome-Wide Prioritization of Disease Genes and Identification of Disease-Disease Associations from an Integrated Human Functional Linkage Networken_US
dc.typearticleen_US
dc.identifier.doi10.1186/gb-2009-10-9-r91
dc.identifier.pubmedid19728866
dc.identifier.pmcid2768980


Files in this item

This item appears in the following Collection(s)

Show simple item record

Copyright 2009 Linghu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2009 Linghu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.