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dc.contributor.authorHoffman, Kateen_US
dc.contributor.authorWebster, Thomas F.en_US
dc.contributor.authorWeisskopf, Marc G.en_US
dc.contributor.authorWeinberg, Janiceen_US
dc.contributor.authorVieira, Verónica M.en_US
dc.date.accessioned2012-01-09T14:34:18Z
dc.date.available2012-01-09T14:34:18Z
dc.date.issued2010-12en_US
dc.identifier.citationHoffman, Kate, Thomas F. Webster, Marc G. Weisskopf, Janice Weinberg, Verónica M. Vieira. "Exposure to Polyfluoroalkyl Chemicals and Attention Deficit/Hyperactivity Disorder in U.S. Children 12-15 Years of Age" Environmental Health Perspectives 118 (12): 1762-1767. (2010)en_US
dc.identifier.issn1552-9924en_US
dc.identifier.urihttp://hdl.handle.net/2144/2777
dc.description.abstractBACKGROUND. Polyfluoroalkyl chemicals (PFCs) have been widely used in consumer products. Exposures in the United States and in world populations are widespread. PFC exposures have been linked to various health impacts, and data in animals suggest that PFCs may be potential developmental neurotoxicants. OBJECTIVES. We evaluated the associations between exposures to four PFCs and parental report of diagnosis of attention deficit/hyperactivity disorder (ADHD). METHODS. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2003-2004 for children 12-15 years of age. Parental report of a previous diagnosis by a doctor or health care professional of ADHD in the child was the primary outcome measure. Perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS) levels were measured in serum samples from each child. RESULTS. Parents reported that 48 of 571 children included in the analysis had been diagnosed with ADHD. The adjusted odds ratio (OR) for parentally reported ADHD in association with a 1-μg/L increase in serum PFOS (modeled as a continuous predictor) was 1.03 [95% confidence interval (CI), 1.01-1.05]. Adjusted ORs for 1-μg/L increases in PFOA and PFHxS were also statistically significant (PFOA: OR = 1.12; 95% CI, 1.01-1.23; PFHxS: OR = 1.06; 95% CI, 1.02-1.11), and we observed a nonsignificant positive association with PFNA (OR = 1.32; 95% CI, 0.86-2.02). CONCLUSIONS. Our results, using cross-sectional data, are consistent with increased odds of ADHD in children with higher serum PFC levels. Given the extremely prevalent exposure to PFCs, follow-up of these data with cohort studies is needed.en_US
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.rightsThis is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.en_US
dc.subjectAttention deficit/hyperactivity disorder (ADHD)en_US
dc.subjectNational Health and Nutrition Examination Survey (NHANES)en_US
dc.subjectPerfluorohexane sulfonic acid (PFHxS)en_US
dc.subjectPerfluorononanoic acid (PFNA)en_US
dc.subjectPerfluorooctane sulfonic acid (PFOS)en_US
dc.subjectPerfluorooctanoic acid (PFOA)en_US
dc.subjectPolyfluoroalkyl chemicals (PFCs)en_US
dc.titleExposure to Polyfluoroalkyl Chemicals and Attention Deficit/Hyperactivity Disorder in U.S. Children 12-15 Years of Ageen_US
dc.typearticleen_US
dc.identifier.doi10.1289/ehp.1001898en_US
dc.identifier.pubmedid20551004en_US
dc.identifier.pmcid3002197en_US


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