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dc.contributor.authorBaja, Emmanuel S.en_US
dc.contributor.authorSchwartz, Joel D.en_US
dc.contributor.authorWellenius, Gregory A.en_US
dc.contributor.authorCoull, Brent A.en_US
dc.contributor.authorZanobetti, Antonellaen_US
dc.contributor.authorVokonas, Pantel S.en_US
dc.contributor.authorSuh, Helen H.en_US
dc.date.accessioned2012-01-09T14:20:01Z
dc.date.available2012-01-09T14:20:01Z
dc.date.issued2010-06en_US
dc.identifier.citationBaja, Emmanuel S., Joel D. Schwartz, Gregory A. Wellenius, Brent A. Coull, Antonella Zanobetti, Pantel S. Vokonas, Helen H. Suh. "Traffic-Related Air Pollution and QT Interval: Modification by Diabetes, Obesity, and Oxidative Stress Gene Polymorphisms in the Normative Aging Study" Environmental Health Perspectives 118(6): 840-846. (2010)en_US
dc.identifier.issn1552-9924en_US
dc.identifier.urihttp://hdl.handle.net/2144/2754
dc.description.abstractBACKGROUND. Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure. OBJECTIVES. We examined the effects of air pollutants on heart-rate-corrected QT interval (QTc), an electrocardiographic marker of ventricular repolarization, and whether these associations were modified by participant characteristics and genetic polymorphisms related to oxidative stress. METHODS. We studied repeated measurements of QTc on 580 men from the Veterans Affairs Normative Aging Study (NAS) using mixed-effects models with random intercepts. We fitted a quadratic constrained distributed lag model to estimate the cumulative effect on QTc of ambient air pollutants including fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5), ozone (O3), black carbon (BC), nitrogen dioxide (NO2), carbon monoxide (CO), and sulfur dioxide (SO2) concentrations during the 10 hr before the visit. We genotyped polymorphisms related to oxidative stress and analyzed pollution-susceptibility score interactions using the genetic susceptibility score (GSS) method. RESULTS. Ambient traffic pollutant concentrations were related to longer QTc. An interquartile range (IQR) change in BC cumulative during the 10 hr before the visit was associated with increased QTc [1.89 msec change; 95% confidence interval (CI), -0.16 to 3.93]. We found a similar association with QTc for an IQR change in 1-hr BC that occurred 4 hr before the visit (2.54 msec change; 95% CI, 0.28-4.80). We found increased QTc for IQR changes in NO2 and CO, but the change was statistically insignificant. In contrast, we found no association between QTc and PM2.5, SO2, and O3. The association between QTc and BC was stronger among participants who were obese, who had diabetes, who were nonsmokers, or who had higher GSSs. CONCLUSIONS. Traffic-related pollutants may increase QTc among persons with diabetes, persons who are obese, and nonsmoking elderly individuals; the number of genetic variants related to oxidative stress increases this effect.en_US
dc.description.sponsorshipNational Institute of Environmental Health Sciences (ES014663-01A2, P01 ES09825); United States Environmental Protection Agency (R827353, R83241601)en_US
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.rightsThis is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.en_US
dc.subjectAir pollutionen_US
dc.subjectDiabetesen_US
dc.subjectDistributed lagsen_US
dc.subjectGenesen_US
dc.subjectObesityen_US
dc.subjectOxidative stressen_US
dc.subjectQT intervalen_US
dc.subjectSmokingen_US
dc.subjectTrafficen_US
dc.titleTraffic-Related Air Pollution and QT Interval: Modification by Diabetes, Obesity, and Oxidative Stress Gene Polymorphisms in the Normative Aging Studyen_US
dc.typearticleen_US
dc.identifier.doi10.1289/ehp.0901396en_US
dc.identifier.pubmedid20194081en_US
dc.identifier.pmcid2898862en_US


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