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dc.contributor.authorPerlstein, Todden_US
dc.contributor.authorWeuve, Jenniferen_US
dc.contributor.authorSchwartz, Joelen_US
dc.contributor.authorSparrow, Daviden_US
dc.contributor.authorWright, Roberten_US
dc.contributor.authorLitonjua, Augustoen_US
dc.contributor.authorNie, Huilingen_US
dc.contributor.authorHu, Howarden_US
dc.date.accessioned2012-01-09T14:19:05Z
dc.date.available2012-01-09T14:19:05Z
dc.date.issued2007-12en_US
dc.identifier.citationPerlstein, Todd, Jennifer Weuve, Joel Schwartz, David Sparrow, Robert Wright, Augusto Litonjua, Huiling Nie, Howard Hu. "Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study" Environmental Health Perspectives 115(12): 1696-1700. (2007)en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://hdl.handle.net/2144/2741
dc.description.abstractBACKGROUND. Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote functional and structural vascular disease. OBJECTIVES. We tested the hypothesis that cumulative community-level lead exposure, measured with K-X-ray fluorescence, is associated with pulse pressure in a cohort of adult men. METHODS AND RESULTS. In a cross-sectional analysis of 593 men not treated with antihypertensive medication, tibia lead was positively associated with pulse pressure (p < 0.001). Adjusting for age, race, diabetes, family history of hypertension, education, waist circumference, alcohol intake, smoking history, height, heart rate, fasting glucose, and total cholesterol-to-HDL ratio, increasing quintiles of tibia lead remained associated with increased pulse pressure (ptrend = 0.02). Men with tibia lead above the median (19.0 μg/g) had, on average, a 4.2-mmHg (95% confidence interval, 1.9-6.5) higher pulse pressure than men with tibia lead level below the median. In contrast, blood lead level was not associated with pulse pressure. CONCLUSIONS. These data indicate that lead exposure may contribute to the observed increase in pulse pressure that occurs with aging in industrialized societies. Lead accumulation may contribute to arterial aging, perhaps providing mechanistic insight into the observed association of low-level lead exposure with cardiovascular mortality.en_US
dc.description.sponsorshipNational Institutes of Health (T32 HL007609, R01-ES05257, P20-MD000501, P42-ES05947, GCRC M01-RR02635, ES03918-02); United States Department of Veterans Affairs; ABIOMED, Inc.en_US
dc.language.isoenen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.subjectAgingen_US
dc.subjectEpidemiologyen_US
dc.subjectHumansen_US
dc.subjectLead exposureen_US
dc.subjectPulse pressureen_US
dc.titleCumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Studyen_US
dc.typearticleen_US
dc.identifier.doi10.1289/ehp.10350en_US
dc.identifier.pubmedid18087585en_US
dc.identifier.pmcid2137129en_US


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