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dc.contributor.authorVanCott, Anne Cen_US
dc.contributor.authorCramer, Joyce Aen_US
dc.contributor.authorCopeland, Laurel Aen_US
dc.contributor.authorZeber, John Een_US
dc.contributor.authorSteinman, Michael Aen_US
dc.contributor.authorDersh, Jeffrey Jen_US
dc.contributor.authorGlickman, Mark Een_US
dc.contributor.authorMortensen, Eric Men_US
dc.contributor.authorAmuan, Megan Een_US
dc.contributor.authorPugh, Mary Joen_US
dc.date.accessioned2011-12-29T23:09:23Z
dc.date.available2011-12-29T23:09:23Z
dc.date.copyright2010en_US
dc.date.issued2010-1-11en_US
dc.identifier.citationVanCott, Anne C, Joyce A Cramer, Laurel A Copeland, John E Zeber, Michael A Steinman, Jeffrey J Dersh, Mark E Glickman, Eric M Mortensen, Megan E Amuan, Mary Jo Pugh. "Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital system." BMC Medicine 8:4. (2010)en_US
dc.identifier.issn1741-7015en_US
dc.identifier.urihttp://hdl.handle.net/2144/2637
dc.description.abstractBACKGROUND: The U.S. Food and Drug Administration (FDA) recently linked antiepileptic drug (AED) exposure to suicide-related behaviors based on meta-analysis of randomized clinical trials. We examined the relationship between suicide-related behaviors and different AEDs in older veterans receiving new AED monotherapy from the Veterans Health Administration (VA), controlling for potential confounders. METHODS: VA and Medicare databases were used to identify veterans 66 years and older, who received a) care from the VA between 1999 and 2004, and b) an incident AED (monotherapy) prescription. Previously validated ICD-9-CM codes were used to identify suicidal ideation or behavior (suicide-related behaviors cases), epilepsy, and other conditions previously associated with suicide-related behaviors. Each case was matched to controls based on prior history of suicide-related behaviors, year of AED prescription, and epilepsy status. RESULTS: The strongest predictor of suicide-related behaviors (N = 64; Controls N = 768) based on conditional logistic regression analysis was affective disorder (depression, anxiety, or post-traumatic stress disorder (PTSD); Odds Ratio 4.42, 95% CI 2.30 to 8.49) diagnosed before AED treatment. Increased suicide-related behaviors were not associated with individual AEDs, including the most commonly prescribed AED in the US - phenytoin. CONCLUSION: Our extensive diagnostic and treatment data demonstrated that the strongest predictor of suicide-related behaviors for older patients newly treated with AED monotherapy was a previous diagnosis of affective disorder. Additional, research using a larger sample is needed to clearly determine the risk of suicide-related behaviors among less commonly used AEDs.en_US
dc.description.sponsorshipDepartment of Veterans Affairs and Health Services Research and Developement Service (IIR-02-274); Virginia Health Services Research and Developement Service Merit Review Entry Program Award (MRP-05-145)en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2010 VanCott et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleSuicide-Related Behaviors in Older Patients with New Anti-Epileptic Drug Use: Data from the VA Hospital Systemen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1741-7015-8-4en_US
dc.identifier.pubmedid20064226en_US
dc.identifier.pmcid2823654en_US


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Copyright 2010 VanCott et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2010 VanCott et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.