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dc.contributor.authorJain, Shilpa H.en_US
dc.contributor.authorMassaro, Joseph M.en_US
dc.contributor.authorHoffmann, Udoen_US
dc.contributor.authorRosito, Guido A.en_US
dc.contributor.authorVasan, Ramachandran S.en_US
dc.contributor.authorRaji, Annaswamyen_US
dc.contributor.authorO'Donnell, Christopher J.en_US
dc.contributor.authorMeigs, James B.en_US
dc.contributor.authorFox, Caroline S.en_US
dc.date.accessioned2011-12-29T23:03:40Z
dc.date.available2011-12-29T23:03:40Z
dc.date.issued2009-2-17en_US
dc.identifier.citationJain, Shilpa H., Joseph M. Massaro, Udo Hoffmann, Guido A. Rosito, Ramachandran S. Vasan, Annaswamy Raji, Christopher J. O'Donnell, James B. Meigs, Caroline S. Fox. "Cross-Sectional Associations Bet ween Abdominal and Thoracic Adipose Tissue Compartments and Adiponectin and Resistin in the Framingham Heart Study" Diabetes Care 32(5): 903-908. (2009)en_US
dc.identifier.issn1935-5548en_US
dc.identifier.urihttp://hdl.handle.net/2144/2632
dc.description.abstractOBJECTIVE: To test the association of regional fat depots with circulating adiponectin and resistin concentrations and to assess the potential mediating effect of adipokines on associations between abdominal fat depots and cardiometabolic risk factors. RESEARCH DESIGN AND METHODS: Participants from the Framingham Heart Study offspring cohort (n = 916, 55% women; mean age 59 years) free of cardiovascular disease underwent computed tomography measurement of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), pericardial fat, and intrathoracic fat volumes and assays of circulating adiponectin and resistin. RESULTS: VAT, SAT, pericardial fat, and intrathoracic fat were negatively correlated with adiponectin (r = −0.19 to −0.34, P < 0.001 [women]; r = −0.15 to −0.26, P < 0.01 [men] except SAT) and positively correlated with resistin (r = 0.16–0.21, P < 0.001 [women]; r = 0.11–0.14, P < 0.05 [men] except VAT). VAT increased the multivariable model R2 for adiponectin from 2–4% to 10–13% and for resistin from 3–4% to 3–6%. Adjustment for adipokines did not fully attenuate associations between VAT, SAT, and cardiometabolic risk factors. CONCLUSIONS: Adiponectin and resistin are correlated with fat depots cross-sectionally, but none of the adipokines can serve as surrogates for the fat depots. Relations between VAT, SAT, and cardiometabolic risk factors were not fully explained by adiponectin or resistin concentrations.en_US
dc.description.sponsorshipNational Insitute's of Health National Heart, Lung, and Blood Institute’s Framingham Heart Study (N01-HC-25195); the National Institutes of Health; National Center for Research Resources; General Clinical Research Centers Program (M01-RR-01066); Career Development Award from the American Diabetes Association; National Institute of Diabetes and Digestive and Kidney Diseases (K24 DK080140, RO1 DK080739); National Heart, Lung, and Blood Institute, National Institutes of Health (2K24HL04334)en_US
dc.language.isoenen_US
dc.publisherAmerican Diabetes Associationen_US
dc.titleCross-Sectional Associations Bet ween Abdominal and Thoracic Adipose Tissue Compartments and Adiponectin and Resistin in the Framingham Heart Studyen_US
dc.typearticleen_US
dc.identifier.doi10.2337/dc08-1733en_US
dc.identifier.pubmedid19223612en_US
dc.identifier.pmcid2671095en_US


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