Show simple item record

dc.contributor.authorVinceti, Marcoen_US
dc.contributor.authorBonvicini, Francescaen_US
dc.contributor.authorRothman, Kenneth Jen_US
dc.contributor.authorVescovi, Lucianoen_US
dc.contributor.authorWang, Feiyueen_US
dc.date.accessioned2011-12-29T22:41:33Z
dc.date.available2011-12-29T22:41:33Z
dc.date.copyright2010en_US
dc.date.issued2010-12-6en_US
dc.identifier.citationVinceti, Marco, Francesca Bonvicini, Kenneth J Rothman, Luciano Vescovi, Feiyue Wang. "The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: a population-based case-control study" Environmental Health 9:77. (2010)en_US
dc.identifier.issn1476-069Xen_US
dc.identifier.urihttp://hdl.handle.net/2144/2602
dc.description.abstractBACKGROUND: A community in northern Italy was previously reported to have an excess incidence of amyotrophic lateral sclerosis among residents exposed to high levels of inorganic selenium in their drinking water. METHODS: To assess the extent to which such association persisted in the decade following its initial observation, we conducted a population-based case-control study encompassing forty-one newly-diagnosed cases of amyotrophic lateral sclerosis and eighty-two age- and sex-matched controls. We measured long-term intake of inorganic selenium along with other potentially neurotoxic trace elements. RESULTS: We found that consumption of drinking water containing ≥ 1 μg/l of inorganic selenium was associated with a relative risk for amyotrophic lateral sclerosis of 5.4 (95% confidence interval 1.1-26) after adjustment for confounding factors. Greater amounts of cumulative inorganic selenium intake were associated with progressively increasing effects, with a relative risk of 2.1 (95% confidence interval 0.5-9.1) for intermediate levels of cumulative intake and 6.4 (95% confidence interval 1.3-31) for high intake. CONCLUSION: Based on these results, coupled with other epidemiologic data and with findings from animal studies that show specific toxicity of the trace element on motor neurons, we hypothesize that dietary intake of inorganic selenium through drinking water increases the risk for amyotrophic lateral sclerosis.en_US
dc.description.sponsorshipPietro Manodori Foundation of Reggio Emilia; Local Health Unit of Reggio Emiliaen_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2010 Vinceti et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.titleThe Relation between Amyotrophic Lateral Sclerosis and Inorganic Selenium in Drinking Water: A Population-Based Case-Control Studyen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1476-069X-9-77en_US
dc.identifier.pubmedid21134276en_US
dc.identifier.pmcid3023780en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record