The Relation between Amyotrophic Lateral Sclerosis and Inorganic Selenium in Drinking Water: A Population-Based Case-Control Study


Show simple item record Vinceti, Marco en_US Bonvicini, Francesca en_US Rothman, Kenneth J en_US Vescovi, Luciano en_US Wang, Feiyue en_US 2011-12-29T22:41:33Z 2011-12-29T22:41:33Z 2010 en_US 2010-12-6 en_US
dc.identifier.citation Vinceti, Marco, Francesca Bonvicini, Kenneth J Rothman, Luciano Vescovi, Feiyue Wang. "The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: a population-based case-control study" Environmental Health 9:77. (2010) en_US
dc.identifier.issn 1476-069X en_US
dc.description.abstract BACKGROUND: A community in northern Italy was previously reported to have an excess incidence of amyotrophic lateral sclerosis among residents exposed to high levels of inorganic selenium in their drinking water. METHODS: To assess the extent to which such association persisted in the decade following its initial observation, we conducted a population-based case-control study encompassing forty-one newly-diagnosed cases of amyotrophic lateral sclerosis and eighty-two age- and sex-matched controls. We measured long-term intake of inorganic selenium along with other potentially neurotoxic trace elements. RESULTS: We found that consumption of drinking water containing ≥ 1 μg/l of inorganic selenium was associated with a relative risk for amyotrophic lateral sclerosis of 5.4 (95% confidence interval 1.1-26) after adjustment for confounding factors. Greater amounts of cumulative inorganic selenium intake were associated with progressively increasing effects, with a relative risk of 2.1 (95% confidence interval 0.5-9.1) for intermediate levels of cumulative intake and 6.4 (95% confidence interval 1.3-31) for high intake. CONCLUSION: Based on these results, coupled with other epidemiologic data and with findings from animal studies that show specific toxicity of the trace element on motor neurons, we hypothesize that dietary intake of inorganic selenium through drinking water increases the risk for amyotrophic lateral sclerosis. en_US
dc.description.sponsorship Pietro Manodori Foundation of Reggio Emilia; Local Health Unit of Reggio Emilia en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2010 Vinceti et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.title The Relation between Amyotrophic Lateral Sclerosis and Inorganic Selenium in Drinking Water: A Population-Based Case-Control Study en_US
dc.type article en_US
dc.identifier.doi 10.1186/1476-069X-9-77 en_US
dc.identifier.pubmedid 21134276 en_US
dc.identifier.pmcid 3023780 en_US

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