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dc.contributor.authorObel, Nielsen_US
dc.contributor.authorReinholdt, Hanneen_US
dc.contributor.authorOmland, Lars Hen_US
dc.contributor.authorEngsig, Frederiken_US
dc.contributor.authorSørensen, Henrik Ten_US
dc.contributor.authorHansen, Ann-Brit Een_US
dc.date.accessioned2011-12-29T22:39:39Z
dc.date.available2011-12-29T22:39:39Z
dc.date.copyright2008en_US
dc.date.issued2008-4-25en_US
dc.identifier.citationObel, Niels, Hanne Reinholdt, Lars H Omland, Frederik Engsig, Henrik T Sørensen, Ann-Brit E Hansen. "Retrivability in The Danish National Hospital Registry of HIV and hepatitis B and C coinfection diagnoses of patients managed in HIV centers 1995–2004" BMC Medical Research Methodology 8:25. (2008)en_US
dc.identifier.issn1471-2288en_US
dc.identifier.urihttp://hdl.handle.net/2144/2586
dc.description.abstractBACKGROUND: Hospital-based discharge registries are used increasingly for longitudinal epidemiological studies of HIV. We examined completeness of registration of HIV infections and of chronic hepatitis B (HBV) and hepatitis C (HCV) coinfections in the Danish National Hospital Registry (DNHR) covering all Danish hospitals. METHODS: The Danish HIV Cohort Study (DHCS) encompasses all HIV-infected patients treated in Danish HIV clinics since 1 January 1995. All 2,033 Danish patients in DHCS diagnosed with HIV-1 during the 10-year period from 1 January 1995 to 31 December 2004 were included in the current analysis. We used the DHCS as a reference to examine the completeness of HIV and of HBV and HCV coinfections recorded in DNHR. Cox regression analysis was used to estimate hazard ratios of time to diagnosis of HIV in DNHR compared to DHCS. RESULTS: Of the 2,033 HIV patients in DHCS, a total of 2,006 (99%) were registered with HIV in DNHR. Of these, 1,888 (93%) were registered in DNHR within one year of their first positive HIV test. A CD4 < 200 cells/μl, a viral load >= 100,000 copies/ml and being diagnosed after 1 January 2000, were associated with earlier registration in DNHR, both in crude and adjusted analyses. Thirty (23%) HIV patients registered with chronic HBV (n = 129) in DHCS and 126 (48%) of HIV patients with HCV (n = 264) in DHCS were registered with these diagnoses in the DNHR. Further 17 and 8 patients were registered with HBV and HCV respectively in DNHR, but not in DHCS. The positive predictive values of being registered with HBV and HCV in DHCS were thereby estimated to 0.88 and 0.97 and in DNHR to 0.32 and 0.54. CONCLUSION: The study demonstrates that secondary data from national hospital databases may be reliable for identification of patients diagnosed with HIV infection. However, the predictive value of co-morbidity data may be low.en_US
dc.description.sponsorshipRoche; Bristol-Myers Squibb; Merck Sharp and Dohme; GlaxoSmithKline; Abbott; Boehringer Ingelheim; Janssen-Cilag; Swedish Orphanen_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2008 Obel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.titleRetrivability in The Danish National Hospital Registry of HIV and Hepatitis B and C Coinfection Diagnoses of Patients Managed in HIV Centers 1995–2004en_US
dc.typearticleen_US
dc.identifier.doi10.1186/1471-2288-8-25en_US
dc.identifier.pubmedid18439245en_US
dc.identifier.pmcid2386497en_US


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Copyright 2008 Obel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2008 Obel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.