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dc.contributor.authorEhrenstein, Boris P.en_US
dc.contributor.authorEhrenstein, Veraen_US
dc.contributor.authorHenke, Christineen_US
dc.contributor.authorLinde, Hans-Jörgen_US
dc.contributor.authorSalzberger, Bernden_US
dc.contributor.authorSchölmerich, Jürgenen_US
dc.contributor.authorGlück, Thomasen_US
dc.date.accessioned2011-12-29T22:39:39Z
dc.date.available2011-12-29T22:39:39Z
dc.date.copyright2008
dc.date.issued2008-10-28
dc.identifier.citationEhrenstein, Boris P, Vera Ehrenstein, Christine Henke, Hans-Jörg Linde, Bernd Salzberger, Jürgen Schölmerich, Thomas Glück. "Risk factors for negative blood cultures in adult medical inpatients – a retrospective analysis." BMC Infectious Diseases8:148. (2008)
dc.identifier.issn1471-2334
dc.identifier.urihttp://hdl.handle.net/2144/2585
dc.description.abstractBACKGROUND: The identification of clinical factors associated with negative blood cultures could help to avoid unnecessary blood cultures. C-reactive protein (CRP) is a well-established inflammation marker commonly used in the management of medical inpatients. METHODS: We studied the association of clinical factors, CRP levels and changes of CRP documented prior to blood culture draws with the absence of bacteremia for hospitalized medical patients. RESULTS: In the retrospective analysis of 710 blood cultures obtained from 310 medical inpatients of non-intensive-care wards during one year (admission blood cultures obtained in the emergency room were excluded), the following retrospectively available factors were the only independent predictors of blood cultures negative for obligate pathogens: a good clinical condition represented by the lowest of three general nursing categories (OR 4.2, 95% CI 1.8 – 9.5), a CRP rise > 50 mg/L documented before the blood culture draw (OR 2.0 95% CI 1.8–9.5) and any antibiotic treatment in the previous seven days (OR 2.0, 95% CI 1.1–3.5). CONCLUSION: Including the general clinical condition, antibiotic pre-treatment and a substantial rise of CRP into the decision, whether or not to obtain blood cultures from medical inpatients with a suspected infection, could improve the diagnostic yield.en_US
dc.description.sponsorshipDepartment of Internal Medicine, University of Regensburg, Germanyen_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsCopyright 2008 Ehrenstein et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.titleRisk Factors for Negative Blood Cultures in Adult Medical Inpatients – a Retrospective Analysisen_US
dc.typearticleen_US
dc.identifier.doi10.1186/1471-2334-8-148
dc.identifier.pubmedid18957115
dc.identifier.pmcid2582035


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Copyright 2008 Ehrenstein et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright 2008 Ehrenstein et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.