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dc.contributor.authorKoido, Shigeoen_US
dc.contributor.authorHomma, Sadamuen_US
dc.contributor.authorHara, Eiichien_US
dc.contributor.authorNamiki, Yoshihisaen_US
dc.contributor.authorTakahara, Akitakaen_US
dc.contributor.authorKomita, Hideoen_US
dc.contributor.authorNagasaki, Eijiroen_US
dc.contributor.authorIto, Masakien_US
dc.contributor.authorOhkusa, Toshifumien_US
dc.contributor.authorGong, Jianlinen_US
dc.contributor.authorTajiri, Hisaoen_US
dc.date.accessioned2011-12-29T21:02:25Z
dc.date.available2011-12-29T21:02:25Z
dc.date.copyright2010en_US
dc.date.issued2010-10-26en_US
dc.identifier.citationKoido, Shigeo, Sadamu Homma, Eiichi Hara, Yoshihisa Namiki, Akitaka Takahara, Hideo Komita, Eijiro Nagasaki, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri. "Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions" Clinical and Developmental Immunology 2010:516768. (2010)en_US
dc.identifier.issn1740-2530en_US
dc.identifier.urihttp://hdl.handle.net/2144/2532
dc.description.abstractThe goal of cancer vaccines is to induce antitumor immunity that ultimately will reduce tumor burden in tumor environment. Several strategies involving dendritic cells- (DCs)- based vaccine incorporating different tumor-associated antigens to induce antitumor immune responses against tumors have been tested in clinical trials worldwide. Although DCs-based vaccine such as fusions of whole tumor cells and DCs has been proven to be clinically safe and is efficient to enhance antitumor immune responses for inducing effective immune response and for breaking T-cell tolerance to tumor-associated antigens (TAAs), only a limited success has occurred in clinical trials. This paper reviews tumor immune escape and current strategies employed in the field of tumor/DC fusions vaccine aimed at enhancing activation of TAAs-specific cytotoxic T cells in tumor microenvironment.en_US
dc.description.sponsorshipFoundation for the Promotion of Cancer Research; Mitsui Life Social Welfare Foundation; Grants-in-Aid for Scientific Research from the Ministry of Education, Cultures, Sports, Science, and Technology of Japan; Grant-in-Aid of the Japan Medical Association; Takeda Science Foundation; Pancreas Research Foundation of Japanen_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rightsCopyright 2010 Koido et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.titleRegulation of Tumor Immunity by Tumor/Dendritic Cell Fusionsen_US
dc.typearticleen_US
dc.identifier.doi10.1155/2010/516768en_US
dc.identifier.pubmedid21048993en_US
dc.identifier.pmcid2964897en_US


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