Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions


Show simple item record Koido, Shigeo en_US Homma, Sadamu en_US Hara, Eiichi en_US Namiki, Yoshihisa en_US Takahara, Akitaka en_US Komita, Hideo en_US Nagasaki, Eijiro en_US Ito, Masaki en_US Ohkusa, Toshifumi en_US Gong, Jianlin en_US Tajiri, Hisao en_US 2011-12-29T21:02:25Z 2011-12-29T21:02:25Z 2010 en_US 2010-10-26 en_US
dc.identifier.citation Koido, Shigeo, Sadamu Homma, Eiichi Hara, Yoshihisa Namiki, Akitaka Takahara, Hideo Komita, Eijiro Nagasaki, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri. "Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions" Clinical and Developmental Immunology 2010:516768. (2010) en_US
dc.identifier.issn 1740-2530 en_US
dc.description.abstract The goal of cancer vaccines is to induce antitumor immunity that ultimately will reduce tumor burden in tumor environment. Several strategies involving dendritic cells- (DCs)- based vaccine incorporating different tumor-associated antigens to induce antitumor immune responses against tumors have been tested in clinical trials worldwide. Although DCs-based vaccine such as fusions of whole tumor cells and DCs has been proven to be clinically safe and is efficient to enhance antitumor immune responses for inducing effective immune response and for breaking T-cell tolerance to tumor-associated antigens (TAAs), only a limited success has occurred in clinical trials. This paper reviews tumor immune escape and current strategies employed in the field of tumor/DC fusions vaccine aimed at enhancing activation of TAAs-specific cytotoxic T cells in tumor microenvironment. en_US
dc.description.sponsorship Foundation for the Promotion of Cancer Research; Mitsui Life Social Welfare Foundation; Grants-in-Aid for Scientific Research from the Ministry of Education, Cultures, Sports, Science, and Technology of Japan; Grant-in-Aid of the Japan Medical Association; Takeda Science Foundation; Pancreas Research Foundation of Japan en_US
dc.language.iso en en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.rights Copyright 2010 Koido et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.title Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions en_US
dc.type article en_US
dc.identifier.doi 10.1155/2010/516768 en_US
dc.identifier.pubmedid 21048993 en_US
dc.identifier.pmcid 2964897 en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search OpenBU


Deposit Materials