Cancer Vaccine by Fusions of Dendritic and Cancer Cells


Show simple item record Koido, Shigeo en_US Hara, Eiichi en_US Homma, Sadamu en_US Namiki, Yoshihisa en_US Ohkusa, Toshifumi en_US Gong, Jianlin en_US Tajiri, Hisao en_US 2011-12-29T21:02:25Z 2011-12-29T21:02:25Z 2009 en_US 2010-2-18 en_US
dc.identifier.citation Koido, Shigeo, Eiichi Hara, Sadamu Homma, Yoshihisa Namiki, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri. "Cancer Vaccine by Fusions of Dendritic and Cancer Cells" 2009:657369. (2010) en_US
dc.identifier.issn 1740-2530 en_US
dc.description.abstract Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Therefore, their use for the active immunotherapy against cancers has been studied with considerable interest. The fusion of DCs with whole tumor cells represents in many ways an ideal approach to deliver, process, and subsequently present a broad array of tumor-associated antigens, including those yet to be unidentified, in the context of DCs-derived costimulatory molecules. DCs/tumor fusion vaccine stimulates potent antitumor immunity in the animal tumor models. In the human studies, T cells stimulated by DC/tumor fusion cells are effective in lysis of tumor cells that are used as the fusion partner. In the clinical trials, clinical and immunological responses were observed in patients with advanced stage of malignant tumors after being vaccinated with DC/tumor fusion cells, although the antitumor effect is not as vigorous as in the animal tumor models. This review summarizes recent advances in concepts and techniques that are providing new impulses to DCs/tumor fusions-based cancer vaccination. en_US
dc.language.iso en en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.rights Copyright 2009 Koido et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.title Cancer Vaccine by Fusions of Dendritic and Cancer Cells en_US
dc.type article en_US
dc.identifier.doi 10.1155/2009/657369 en_US
dc.identifier.pubmedid 20182533 en_US
dc.identifier.pmcid 2825547 en_US

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