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dc.contributor.authorKoido, Shigeoen_US
dc.contributor.authorHara, Eiichien_US
dc.contributor.authorHomma, Sadamuen_US
dc.contributor.authorNamiki, Yoshihisaen_US
dc.contributor.authorOhkusa, Toshifumien_US
dc.contributor.authorGong, Jianlinen_US
dc.contributor.authorTajiri, Hisaoen_US
dc.date.accessioned2011-12-29T21:02:25Z
dc.date.available2011-12-29T21:02:25Z
dc.date.copyright2009en_US
dc.date.issued2010-2-18en_US
dc.identifier.citationKoido, Shigeo, Eiichi Hara, Sadamu Homma, Yoshihisa Namiki, Toshifumi Ohkusa, Jianlin Gong, Hisao Tajiri. "Cancer Vaccine by Fusions of Dendritic and Cancer Cells" 2009:657369. (2010)en_US
dc.identifier.issn1740-2530en_US
dc.identifier.urihttp://hdl.handle.net/2144/2531
dc.description.abstractDendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Therefore, their use for the active immunotherapy against cancers has been studied with considerable interest. The fusion of DCs with whole tumor cells represents in many ways an ideal approach to deliver, process, and subsequently present a broad array of tumor-associated antigens, including those yet to be unidentified, in the context of DCs-derived costimulatory molecules. DCs/tumor fusion vaccine stimulates potent antitumor immunity in the animal tumor models. In the human studies, T cells stimulated by DC/tumor fusion cells are effective in lysis of tumor cells that are used as the fusion partner. In the clinical trials, clinical and immunological responses were observed in patients with advanced stage of malignant tumors after being vaccinated with DC/tumor fusion cells, although the antitumor effect is not as vigorous as in the animal tumor models. This review summarizes recent advances in concepts and techniques that are providing new impulses to DCs/tumor fusions-based cancer vaccination.en_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rightsCopyright 2009 Koido et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.titleCancer Vaccine by Fusions of Dendritic and Cancer Cellsen_US
dc.typearticleen_US
dc.identifier.doi10.1155/2009/657369en_US
dc.identifier.pubmedid20182533en_US
dc.identifier.pmcid2825547en_US


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