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dc.contributor.authorFarny, Caleb H.
dc.date.accessioned2010-11-29T16:53:32Z
dc.date.available2010-11-29T16:53:32Z
dc.date.issued2004
dc.identifier.urihttp://hdl.handle.net/2144/1381
dc.description.abstractUnstable arterial plaque is likely the key component of atherosclerosis, a disease which is responsible for two-thirds of heart attacks and strokes, leading to approximately 1 million deaths in the United States. Ultrasound imaging is able to detect plaque but as of yet is not able to distinguish unstable plaque from stable plaque. In this work a scanning acoustic microscope (SAM) was implemented and validated as tool to measure the acoustic properties of a sample. The goal for the SAM is to be able to provide quantitative measurements of the acoustic properties of different plaque types, to understand the physical basis by which plaque may be identified acoustically. The SAM consists of a spherically focused transducer which operates in pulse-echo mode and is scanned in a 2D raster pattern over a sample. A plane wave analysis is presented which allows the impedance, attenuation and phase velocity of a sample to be de- termined from measurements of the echoes from the front and back of the sample. After the measurements, the attenuation and phase velocity were analysed to ensure that they were consistent with causality. The backscatter coefficient of the samples was obtained using the technique outlined by Chen et al [8]. The transducer used here was able to determine acoustic properties from 10-40 MHz. The results for the impedance, attenuation and phase velocity were validated for high and low-density polyethylene against published results. The plane wave approximation was validated by measuring the properties throughout the focal region and throughout a range of incidence angles from the transducer. The SAM was used to characterize a set of recipes for tissue-mimicking phantoms which demonstrate indepen- dent control over the impedance, attenuation, phase velocity and backscatter coefficient. An initial feasibility study on a human artery was performed.en_US
dc.description.sponsorshipThis work was supported in part by CenSSIS the Center for Subsurface Sensing and Imaging Systems under the Engineering Research Centers Program of the National Science Foundation (Award EEC- 9986821)en_US
dc.language.isoen_USen_US
dc.publisherBoston Universityen_US
dc.rightsAttribution 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/*
dc.subjectUltrasounden_US
dc.subjectIntravascular ultrasounden_US
dc.subjectScanning acoustic microscopeen_US
dc.subjectAcoustic attenuationen_US
dc.titleSCANNING ACOUSTIC MICROSCOPE FOR CHARACTERIZATION OF ARTERIAL PLAQUEen_US
dc.typeThesisen_US


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Attribution 3.0 Unported
Except where otherwise noted, this item's license is described as Attribution 3.0 Unported